Adora1-KO 基因敲除小鼠

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产品名称

Adora1-KO 基因敲除小鼠

产品编号

S-KO-00934

品系全称

C57BL/6JCya-Adora1em1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-11539-Adora1-B6J-VA

品系状态

使用本品系发表的文献需注明: Adora1-KO 基因敲除小鼠 mice (Strain S-KO-00934) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
adenosine A1 receptor
基因别称
A1-AR,A1AR,A1R,AA1R,ARA1,Ri
染色体号
Chr 1 (Mouse)
转录本 ID
NCBI: NM_001039510 | Ensembl: ENSMUST00000086465
修饰方式
全身性基因敲除
靶向范围
Exon 3
敲除长度
~1.5 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:99401Homozygotes for a null allele exhibit allodynia, hyperalgesia, increased anxiety, and decreased hypoxic neuroprotection. Homozygotes for a different null allele show increased susceptibility to kidney reperfusion injury and absent tubuloglomerular feedback response.
Adora1,也称为Adenosine A1 Receptor,是一种G蛋白偶联受体,负责结合腺苷并调节细胞内的信号传导。Adora1在人体内广泛表达,尤其是在中枢神经系统中,对神经传递和神经元功能发挥着重要作用。此外,Adora1还参与调节免疫反应、细胞生长和凋亡等过程。

Adora1的异常表达与多种疾病的发生发展密切相关。例如,Adora1在鼻咽癌中的过表达与肿瘤细胞的增殖、侵袭和迁移有关[1]。在乳头状甲状腺癌中,Adora1的过表达与淋巴转移和病理分期相关,并且具有诊断和预后价值[2]。此外,Adora1的突变与早发性帕金森病和认知功能障碍有关[4]。Adora1基因的遗传变异还与精神分裂症的发病机制相关[5]。Adora1的过表达在急性右心室衰竭的肉鸡中也得到了证实[8]。

除了与疾病相关的研究,Adora1的功能还涉及到其他生物学过程。例如,Adora1在调节细胞对缺氧的敏感性方面发挥作用[3]。此外,Adora1在1型糖尿病的发病机制中也有重要作用,其功能丧失可能导致α细胞缺陷和β细胞应激[6]。Adora1还与卵巢癌的进展相关,可能是治疗卵巢癌的潜在靶点[7]。

综上所述,Adora1作为一种重要的G蛋白偶联受体,在多种生物学过程中发挥着关键作用。Adora1的异常表达与多种疾病的发生发展密切相关,包括鼻咽癌、甲状腺癌、帕金森病、精神分裂症、1型糖尿病和卵巢癌等。此外,Adora1还参与调节细胞对缺氧的敏感性。深入研究Adora1的功能和作用机制,有助于理解相关疾病的发病机制,并为疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Pan, Suming, Liang, Sixian, Wang, Xianyan. 2021. ADORA1 promotes nasopharyngeal carcinoma cell progression through regulation of PI3K/AKT/GSK-3β/β-catenin signaling. In Life sciences, 278, 119581. doi:10.1016/j.lfs.2021.119581. https://pubmed.ncbi.nlm.nih.gov/33961854/
2. Lin, Xu, Wang, Zhi-Yong, Xue, Gang, Wu, Jing-Fang, Zhang, Geng. 2021. ADORA1 is a diagnostic-related biomarker and correlated with immune infiltrates in papillary thyroid carcinoma. In Journal of Cancer, 12, 3997-4010. doi:10.7150/jca.50743. https://pubmed.ncbi.nlm.nih.gov/34093805/
3. Wong, Poh Kuan, Syafruddin, Saiful Effendi, Cheah, Fook Choe, Ng, Pei Yuen, Chua, Eng Wee. 2024. Introduction of a single-nucleotide variant, rs16851030, into the ADORA1 gene increased cellular susceptibility to hypoxia. In Personalized medicine, 21, 353-366. doi:10.1080/17410541.2024.2412514. https://pubmed.ncbi.nlm.nih.gov/39440484/
4. Jaberi, Elham, Rohani, Mohammad, Shahidi, Gholam Ali, Steemers, Frank, Elahi, Elahe. 2016. Mutation in ADORA1 identified as likely cause of early-onset parkinsonism and cognitive dysfunction. In Movement disorders : official journal of the Movement Disorder Society, 31, 1004-11. doi:10.1002/mds.26627. https://pubmed.ncbi.nlm.nih.gov/27134041/
5. Gotoh, Leo, Mitsuyasu, Hiroshi, Kobayashi, Yuki, Kawasaki, Hiroaki, Kanba, Shigenobu. . Association analysis of adenosine A1 receptor gene (ADORA1) polymorphisms with schizophrenia in a Japanese population. In Psychiatric genetics, 19, 328-35. doi:10.1097/YPG.0b013e3283328e26. https://pubmed.ncbi.nlm.nih.gov/19820430/
6. Yip, Linda, Fathman, C Garrison. . Type 1 diabetes in mice and men: gene expression profiling to investigate disease pathogenesis. In Immunologic research, 58, 340-50. doi:10.1007/s12026-014-8501-8. https://pubmed.ncbi.nlm.nih.gov/24682832/
7. Nomiri, Samira, Karami, Hassan, Baradaran, Behzad, Safarpour, Hossein, Silvestris, Nicola. 2021. Exploiting systems biology to investigate the gene modules and drugs in ovarian cancer: A hypothesis based on the weighted gene co-expression network analysis. In Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 146, 112537. doi:10.1016/j.biopha.2021.112537. https://pubmed.ncbi.nlm.nih.gov/34922114/
8. Kamely, Mohammad, Karimi Torshizi, Mohammad Amir, Wideman, Robert F, West, James. 2017. Upregulation of SERT and ADORA1 in broilers with acute right ventricular failure. In Research in veterinary science, 125, 397-400. doi:10.1016/j.rvsc.2017.09.030. https://pubmed.ncbi.nlm.nih.gov/29174607/