MGI:2140796Mice homozygous for an ENU-induced mutation display abrogation of both Toll-like receptor (TLR)-induced type I IFN and proinflammatory cytokine production by plasmacytoid dendritic cells. Mice homozygous for a knock-out allele show impaired TLR9-and NOD1-mediated cytokine production and decreased susceptibility to DSS-induced colitis.