Gcn1-flox 基因敲除小鼠

1. Müller, Martin B D, Kasturi, Prasad, Jayaraj, Gopal G, Hartl, F Ulrich. 2023. Mechanisms of readthrough mitigation reveal principles of GCN1-mediated translational quality control. In Cell, 186, 3227-3244.e20. doi:10.1016/j.cell.2023.05.035. https://pubmed.ncbi.nlm.nih.gov/37339632/

2. Pochopien, Agnieszka A, Beckert, Bertrand, Kasvandik, Sergo, Tenson, Tanel, Wilson, Daniel N. . Structure of Gcn1 bound to stalled and colliding 80S ribosomes. In Proceedings of the National Academy of Sciences of the United States of America, 118, . doi:10.1073/pnas.2022756118. https://pubmed.ncbi.nlm.nih.gov/33790014/

3. Lee, Su Jung, Swanson, Mark J, Sattlegger, Evelyn. . Gcn1 contacts the small ribosomal protein Rps10, which is required for full activation of the protein kinase Gcn2. In The Biochemical journal, 466, 547-59. doi:10.1042/BJ20140782. https://pubmed.ncbi.nlm.nih.gov/25437641/

4. Marton, M J, Crouch, D, Hinnebusch, A G. . GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2. In Molecular and cellular biology, 13, 3541-56. doi:. https://pubmed.ncbi.nlm.nih.gov/8497269/

5. Sattlegger, E, Hinnebusch, A G. . Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells. In The EMBO journal, 19, 6622-33. doi:. https://pubmed.ncbi.nlm.nih.gov/11101534/