Polr2a-flox 基因敲除小鼠

1. Hou, Shuai, Qu, Dajun, Li, Yue, Zhang, Liye, Lei, Haixin. . XAB2 depletion induces intron retention in POLR2A to impair global transcription and promote cellular senescence. In Nucleic acids research, 47, 8239-8254. doi:10.1093/nar/gkz532. https://pubmed.ncbi.nlm.nih.gov/31216022/

2. Liu, Chuxiao, Han, Yu, Zhao, Xingyu, Li, Dongsong, Li, Guangyu. 2021. POLR2A blocks osteoclastic bone resorption and protects against osteoporosis by interacting with CREB1. In Journal of cellular physiology, 236, 5134-5146. doi:10.1002/jcp.30220. https://pubmed.ncbi.nlm.nih.gov/33595106/

3. Paparella, Roberto, Caroleo, Anna Maria, Agolini, Emanuele, Tartaglia, Marco, Mastronuzzi, Angela. 2022. Posterior fossa ependymoma in neurodevelopmental syndrome caused by a de novo germline pathogenic POLR2A variant. In American journal of medical genetics. Part A, 188, 2796-2802. doi:10.1002/ajmg.a.62869. https://pubmed.ncbi.nlm.nih.gov/35689525/

4. Xu, Jiangsheng, Liu, Yunhua, Li, Yujing, Lu, Xiongbin, He, Xiaoming. 2019. Precise targeting of POLR2A as a therapeutic strategy for human triple negative breast cancer. In Nature nanotechnology, 14, 388-397. doi:10.1038/s41565-019-0381-6. https://pubmed.ncbi.nlm.nih.gov/30804480/