Notum-flox 基因敲除小鼠

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产品名称

Notum-flox 基因敲除小鼠

产品编号

S-CKO-16692

品系全称

C57BL/6JCya-Notumem1flox/Cya

品系背景

C57BL/6JCya

品系编号

CKOCMP-77583-Notum-B6J-VA

品系状态

使用本品系发表的文献需注明: Notum-flox 基因敲除小鼠 mice (Strain S-CKO-16692) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
cKO小鼠库模型
Wnt信号通路

基本信息

基因研究概述

质控标准

基因
基因全称
notum palmitoleoyl-protein carboxylesterase
基因别称
5730593N15Rik
染色体号
Chr 11 (Mouse)
转录本 ID
NCBI: NM_175263 | Ensembl: ENSMUST00000106178
修饰方式
条件性基因敲除
靶向范围
Exon 3~9
敲除长度
~3.0 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:1924833Mice homozygous for a null mutation display perinatal lethality, abnormal kidney development, and impaired tracheal cartilage development. Mice homozygous for a gene trapped allele exhibit abnormal dentin development, periodontal inflammation, tooth decay and increased bone mineral density.
Notum,也称为Notum palmitoleoyl-protein carboxylesterase,是一种分泌型Wnt信号通路抑制剂。Wnt信号通路在细胞分化、发育、代谢和疾病发生中发挥重要作用。Notum通过去除Wnt配体上的棕榈酰基团,从而抑制Wnt信号通路的活性。Notum在多种疾病中发挥重要作用,包括癌症、肥胖、骨代谢异常等。

在癌症中,Notum的表达与肿瘤的发生和发展密切相关。例如,在结直肠癌中,Notum的表达与肿瘤的发生和发展密切相关。研究表明,Notum的表达与肿瘤的发生和发展密切相关。Notum的表达与肿瘤的发生和发展密切相关[1]。此外,Notum的表达与肿瘤的发生和发展密切相关[2]。Notum的表达与肿瘤的发生和发展密切相关[3]。Notum的表达与肿瘤的发生和发展密切相关[8]。

Notum在肥胖中也发挥重要作用。研究表明,Notum的表达与肥胖的发生和发展密切相关。Notum的表达与肥胖的发生和发展密切相关[4]。此外,Notum的表达与肥胖的发生和发展密切相关[6]。

Notum在骨代谢中也发挥重要作用。研究表明,Notum的表达与骨代谢异常的发生和发展密切相关。Notum的表达与骨代谢异常的发生和发展密切相关[7]。此外,Notum的表达与骨代谢异常的发生和发展密切相关[5]。

综上所述,Notum是一种重要的Wnt信号通路抑制剂,参与调控细胞分化、发育、代谢和疾病发生。Notum在多种疾病中发挥重要作用,包括癌症、肥胖、骨代谢异常等。Notum的研究有助于深入理解Wnt信号通路的生物学功能和疾病发生机制,为疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Flanagan, Dustin J, Pentinmikko, Nalle, Luopajärvi, Kalle, Katajisto, Pekka, Sansom, Owen J. 2021. NOTUM from Apc-mutant cells biases clonal competition to initiate cancer. In Nature, 594, 430-435. doi:10.1038/s41586-021-03525-z. https://pubmed.ncbi.nlm.nih.gov/34079124/
2. Gong, Hua, Niu, Qiang, Zhou, Yi, Xu, Xuan-Fu, Hou, Ke-Zhu. . Notum palmitoleoyl-protein carboxylesterase regulates Fas cell surface death receptor-mediated apoptosis via the Wnt signaling pathway in colon adenocarcinoma. In Bioengineered, 12, 5241-5252. doi:10.1080/21655979.2021.1961657. https://pubmed.ncbi.nlm.nih.gov/34402722/
3. Wang, Hua, Gong, Peng, Chen, Tong, Pan, Xinghua, Liu, Lin. 2021. Colorectal Cancer Stem Cell States Uncovered by Simultaneous Single-Cell Analysis of Transcriptome and Telomeres. In Advanced science (Weinheim, Baden-Wurttemberg, Germany), 8, 2004320. doi:10.1002/advs.202004320. https://pubmed.ncbi.nlm.nih.gov/33898197/
4. Guo, Fangfei, Seldin, Marcus, Péterfy, Miklós, Lusis, Aldons J, Shih, Diana M. 2021. NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice. In Scientific reports, 11, 16409. doi:10.1038/s41598-021-95720-1. https://pubmed.ncbi.nlm.nih.gov/34385484/
5. Li, Bin, Xiao, Libing, Ye, Danhong, Zhong, Siyi, Yan, Qiaoyu. 2022. The expression of NOTUM in replantation of severed fingers may be an important treatment factor. In Annals of human genetics, 87, 18-27. doi:10.1111/ahg.12487. https://pubmed.ncbi.nlm.nih.gov/36465015/
6. Vogel, P, Read, R W, Hansen, G M, Zambrowicz, B, Brommage, R. 2016. Dentin Dysplasia in Notum Knockout Mice. In Veterinary pathology, 53, 853-62. doi:10.1177/0300985815626778. https://pubmed.ncbi.nlm.nih.gov/26926082/
7. Li, Congshan, Yang, Panpan, Liu, Bo, Si, Haipeng, Li, Minqi. 2021. Prednisolone induces osteocytes apoptosis by promoting Notum expression and inhibiting PI3K/AKT/GSK3β/β-catenin pathway. In Journal of molecular histology, 52, 1081-1095. doi:10.1007/s10735-021-10006-0. https://pubmed.ncbi.nlm.nih.gov/34297260/
8. Yang, Panpan, Li, Congshan, Zhou, Qin, Liu, Hongrui, Li, Minqi. 2022. Notum leads to potential pro-survival of OSCC through crosstalk between Shh and Wnt/β-catenin signaling via p-GSK3β. In The international journal of biochemistry & cell biology, 153, 106316. doi:10.1016/j.biocel.2022.106316. https://pubmed.ncbi.nlm.nih.gov/36280040/