Rftn1,也称为raftlin脂筏连接蛋白1,是一种重要的脂筏连接蛋白。脂筏是细胞膜上的微结构域,富含胆固醇和鞘脂,参与细胞信号传导、膜蛋白定位和细胞内吞等生物学过程。Rftn1通过与脂筏的结合,参与调控脂筏的形成和功能,影响细胞的生物学行为。
Rftn1在多种疾病中发挥重要作用,包括胃癌、小细胞肺癌、精神分裂症、脑瘤和青光眼等。在胃癌中,Rftn1通过调节AKT/p38信号通路促进肿瘤细胞的增殖和凋亡,可能作为胃癌的预后指标和治疗靶点[1]。在小细胞肺癌中,Rftn1是染色体3p基因之一,与细胞周期密切相关,可能作为小细胞肺癌的诊断标志物[2]。在精神分裂症中,Rftn1的表达存在性别差异,可能与精神分裂症的发病机制有关[3,5]。在脑瘤中,Rftn1的表达存在性别差异,可能与脑瘤的治疗和预后相关[5,6]。在青光眼中,Rftn1与青光眼相关的视盘参数和角膜厚度相关,可能与青光眼的发病机制有关[4,7]。
此外,Rftn1还与吸烟行为有关,可能通过调节免疫反应或与糖皮质激素受体α和雄激素受体相互作用,影响吸烟行为[3]。Rftn1还与慢性化脓性中耳炎的炎症反应有关,Lactobacillus可能通过抑制Rftn1的表达,减轻慢性化脓性中耳炎的炎症反应[8]。
参考文献:
1. Deng, Chaowei, Zhang, Lu, Ma, Xiaoping, Jia, Yuzhen, Zhao, Lingyu. 2022. RFTN1 facilitates gastric cancer progression by modulating AKT/p38 signaling pathways. In Pathology, research and practice, 234, 153902. doi:10.1016/j.prp.2022.153902. https://pubmed.ncbi.nlm.nih.gov/35490655/
2. Ma, Chunxu, Zhao, Jihua, Wu, Ying, Wang, Jun, Wang, Hao. 2022. Diagnostic value of abnormal chromosome 3p genes in small-cell lung cancer. In Oncology letters, 24, 209. doi:10.3892/ol.2022.13330. https://pubmed.ncbi.nlm.nih.gov/35720498/
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4. Chen, Jian-Huan, Wang, Degui, Huang, Chukai, Pang, Chi-Pui, Zhang, Mingzhi. 2012. Interactive effects of ATOH7 and RFTN1 in association with adult-onset primary open-angle glaucoma. In Investigative ophthalmology & visual science, 53, 779-85. doi:10.1167/iovs.11-8277. https://pubmed.ncbi.nlm.nih.gov/22222511/
5. Adanty, Christopher, Qian, Jessica, Al-Chalabi, Nzaar, Graff, Ariel, De Luca, Vincenzo. 2021. Sex differences in schizophrenia: a longitudinal methylome analysis. In Journal of neural transmission (Vienna, Austria : 1996), 129, 105-114. doi:10.1007/s00702-021-02439-4. https://pubmed.ncbi.nlm.nih.gov/34966975/
6. Mestnik, Shelby, Sorajja, Natali, Lu, Zhanni, Mills, Lauren J, Williams, Lindsay. . Sex Differences in Ependymoma Methylation by Methylation-Defined Subgroup. In Journal of cellular and molecular medicine, 28, e70286. doi:10.1111/jcmm.70286. https://pubmed.ncbi.nlm.nih.gov/39679838/
7. Dai, Min, Hu, Zhulin, Kang, Zefeng, Zheng, Zhikun. 2022. Based on multiple machine learning to identify the ENO2 as diagnosis biomarkers of glaucoma. In BMC ophthalmology, 22, 155. doi:10.1186/s12886-022-02350-w. https://pubmed.ncbi.nlm.nih.gov/35366826/
8. Vo, Phuc Thi-Duy, Choi, Sun Shim, Park, Hae Ryoun, Jeong, Sung-Hee, Choi, Youngnim. 2021. Gene signatures associated with barrier dysfunction and infection in oral lichen planus identified by analysis of transcriptomic data. In PloS one, 16, e0257356. doi:10.1371/journal.pone.0257356. https://pubmed.ncbi.nlm.nih.gov/34506598/