Lonrf3,也称为环指蛋白223(Ring Finger Protein 223, RNF223),是一种E3泛素连接酶。E3泛素连接酶在细胞内的蛋白质降解过程中发挥着重要作用,它们负责将泛素从泛素结合酶转移到特定的蛋白质底物上,从而标记这些蛋白质进行降解。这种蛋白质降解过程在调控细胞周期、信号转导、基因表达和蛋白质稳态等方面都至关重要。RNF223通过其环指结构域与底物相互作用,并介导泛素化,进而影响多种生物学过程。
1. Feng, Lei, Wang, Jieqing, Zhang, Jianmin, Gao, Yi, Zhou, Chenjie. 2021. Comprehensive Analysis of E3 Ubiquitin Ligases Reveals Ring Finger Protein 223 as a Novel Oncogene Activated by KLF4 in Pancreatic Cancer. In Frontiers in cell and developmental biology, 9, 738709. doi:10.3389/fcell.2021.738709. https://pubmed.ncbi.nlm.nih.gov/34722520/