MGI:1921256Mice homozygous for a knock-out allele exhibit embryonic lethality at E11.5 with internal hemorrhage and small size. Mice heterozygous for an ENU induced allele have dilated cardiomyopathy and congestive heart failure, homozygous are embryonic lethal with posterior truncation at E11.5. Brain isoform-specific KO results in ectopic dendrite growth in the hippocampus and enhanced sensorimotor gating.