MGI:1096875Mice homozygous for hypomorphic mutations of this gene exhibit perinatal lethality, altered neural progenitor divisions and neuronal migration, a regionally enlarged cerebral cortex, and focal cortical dysplasia. Homozygotes for a null allele show embryonic and neonatal lethality, congenital heart defects including VSD, overriding aorta and DORV, thin ventricular wall, dilated ventricles, and disorganized ventricular trabeculation.