Tmem127-flox 基因敲除小鼠

1. Chen, Xufeng, Lu, Qiao, Zhou, Hua, Aifantis, Iannis, Wang, Jun. 2023. A membrane-associated MHC-I inhibitory axis for cancer immune evasion. In Cell, 186, 3903-3920.e21. doi:10.1016/j.cell.2023.07.016. https://pubmed.ncbi.nlm.nih.gov/37557169/

2. Bausch, Birke, Schiavi, Francesca, Ni, Ying, Eng, Charis, Neumann, Hartmut P H. . Clinical Characterization of the Pheochromocytoma and Paraganglioma Susceptibility Genes SDHA, TMEM127, MAX, and SDHAF2 for Gene-Informed Prevention. In JAMA oncology, 3, 1204-1212. doi:10.1001/jamaoncol.2017.0223. https://pubmed.ncbi.nlm.nih.gov/28384794/

3. Guo, Qianjin, Cheng, Zi-Ming, Gonzalez-Cantú, Hector, Aguiar, Ricardo C T, Dahia, Patricia L M. 2023. TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation. In Cell reports, 42, 113070. doi:10.1016/j.celrep.2023.113070. https://pubmed.ncbi.nlm.nih.gov/37659079/

4. Qin, Y, Deng, Y, Ricketts, C J, Maher, E R, Dahia, P L M. 2013. The tumor susceptibility gene TMEM127 is mutated in renal cell carcinomas and modulates endolysosomal function. In Human molecular genetics, 23, 2428-39. doi:10.1093/hmg/ddt638. https://pubmed.ncbi.nlm.nih.gov/24334765/