Wtap-flox 基因敲除小鼠

1. Chen, Yunhao, Peng, Chuanhui, Chen, Junru, Wu, Jian, Zheng, Shusen. 2019. WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1. In Molecular cancer, 18, 127. doi:10.1186/s12943-019-1053-8. https://pubmed.ncbi.nlm.nih.gov/31438961/

2. Wan, Zixian, Ye, Lu, Chen, Guange, Zhang, Qiushi, Hua, Wenfeng. 2023. WTAP gene variants and susceptibility to ovarian endometriosis in a Chinese population. In Frontiers in genetics, 14, 1276099. doi:10.3389/fgene.2023.1276099. https://pubmed.ncbi.nlm.nih.gov/37900186/

3. Lan, Jianzi, Xu, Bowen, Shi, Xin, Pan, Qi, Tao, Qing. 2022. WTAP-mediated N6-methyladenosine modification of NLRP3 mRNA in kidney injury of diabetic nephropathy. In Cellular & molecular biology letters, 27, 51. doi:10.1186/s11658-022-00350-8. https://pubmed.ncbi.nlm.nih.gov/35761192/

4. Li, Xinzhi, Ding, Kaixin, Li, Xueying, Chen, Xiao-Wei, Chen, Zheng. 2022. Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH). In Nature communications, 13, 4549. doi:10.1038/s41467-022-32163-w. https://pubmed.ncbi.nlm.nih.gov/35927268/

5. Tang, Jue, Lu, Hongting, Yang, Zhonghua, He, Jing, Liu, Wei. . Associations between WTAP gene polymorphisms and neuroblastoma susceptibility in Chinese children. In Translational pediatrics, 10, 146-152. doi:10.21037/tp-20-168. https://pubmed.ncbi.nlm.nih.gov/33633946/