Mettl3-flox 基因敲除小鼠

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2. Song, Rong-Hua, Liu, Xue-Rong, Gao, Chao-Qun, Du, Peng, Zhang, Jin-An. 2020. METTL3 gene polymorphisms contribute to susceptibility to autoimmune thyroid disease. In Endocrine, 72, 495-504. doi:10.1007/s12020-020-02503-1. https://pubmed.ncbi.nlm.nih.gov/33025559/

3. Lin, Zhen, Hsu, Phillip J, Xing, Xudong, He, Chuan, Tong, Ming-Han. 2017. Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis. In Cell research, 27, 1216-1230. doi:10.1038/cr.2017.117. https://pubmed.ncbi.nlm.nih.gov/28914256/

4. Li, Xinzhi, Yuan, Bingchuan, Lu, Min, Xie, Liwei, Chen, Zheng. 2021. The methyltransferase METTL3 negatively regulates nonalcoholic steatohepatitis (NASH) progression. In Nature communications, 12, 7213. doi:10.1038/s41467-021-27539-3. https://pubmed.ncbi.nlm.nih.gov/34893641/

5. Barbieri, Isaia, Tzelepis, Konstantinos, Pandolfini, Luca, Vassiliou, George S, Kouzarides, Tony. 2017. Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control. In Nature, 552, 126-131. doi:10.1038/nature24678. https://pubmed.ncbi.nlm.nih.gov/29186125/

6. Du, Yuzhang, Hou, Guofang, Zhang, Hailong, Zhao, Xian, Yu, Jianxiu. . SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function. In Nucleic acids research, 46, 5195-5208. doi:10.1093/nar/gky156. https://pubmed.ncbi.nlm.nih.gov/29506078/

7. Song, Huiwen, Feng, Xing, Zhang, Heng, Zhao, Yongxiang, Zhang, Zhiyong. 2019. METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes. In Autophagy, 15, 1419-1437. doi:10.1080/15548627.2019.1586246. https://pubmed.ncbi.nlm.nih.gov/30870073/