Irf3-flox 基因敲除小鼠

1. Yang, Shuai, Jin, Shouheng, Xian, Huifang, Li, Mengqiu, Cui, Jun. 2023. Metabolic enzyme UAP1 mediates IRF3 pyrophosphorylation to facilitate innate immune response. In Molecular cell, 83, 298-313.e8. doi:10.1016/j.molcel.2022.12.007. https://pubmed.ncbi.nlm.nih.gov/36603579/

2. Mao, Yun, Luo, Wei, Zhang, Lin, Wang, Xing Li, Shen, Ying H. 2017. STING-IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced Obesity. In Arteriosclerosis, thrombosis, and vascular biology, 37, 920-929. doi:10.1161/ATVBAHA.117.309017. https://pubmed.ncbi.nlm.nih.gov/28302626/

3. Joshi, Radhika, Brezani, Veronika, Mey, Gabrielle M, Gracia-Sancho, Jordi, Szabo, Gyongyi. 2024. IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer's disease. In Journal of neuroinflammation, 21, 212. doi:10.1186/s12974-024-03203-7. https://pubmed.ncbi.nlm.nih.gov/39215356/

4. Andrilenas, Kellen K, Ramlall, Vijendra, Kurland, Jesse, Harbaugh, Allen G, Siggers, Trevor. . DNA-binding landscape of IRF3, IRF5 and IRF7 dimers: implications for dimer-specific gene regulation. In Nucleic acids research, 46, 2509-2520. doi:10.1093/nar/gky002. https://pubmed.ncbi.nlm.nih.gov/29361124/

5. Yoneyama, Mitsutoshi, Kikuchi, Mika, Natsukawa, Takashi, Akira, Shizuo, Fujita, Takashi. 2004. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. In Nature immunology, 5, 730-7. doi:. https://pubmed.ncbi.nlm.nih.gov/15208624/