Tlr5-flox 基因敲除小鼠

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产品名称

Tlr5-flox 基因敲除小鼠

产品编号

S-CKO-11638

品系全称

C57BL/6JCya-Tlr5em1flox/Cya

品系背景

C57BL/6JCya

品系编号

CKOCMP-53791-Tlr5-B6J-VA

品系状态

使用本品系发表的文献需注明: Tlr5-flox 基因敲除小鼠 mice (Strain S-CKO-11638) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
cKO小鼠库模型

基本信息

基因研究概述

质控标准

基因
基因全称
toll-like receptor 5
基因别称
-
染色体号
Chr 1 (Mouse)
转录本 ID
NCBI: XM_017321703 | Ensembl: ENSMUST00000193687
修饰方式
条件性基因敲除
靶向范围
Exon 4
敲除长度
~2.9 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:1858171Mice homozygous for disruption of this gene have a generally normal phenotype. However they fail to respond immunologically to purified flagellin and are resistant to infection with Salmonella typhimurium.
Toll-like receptor 5 (TLR5) 是一种模式识别受体,主要识别细菌鞭毛蛋白(flagellin)[1]。TLR5 通过激活先天性和适应性免疫反应,在控制肠道稳态中发挥着重要作用[5]。TLR5 的激活可以促进肝细胞增殖,增强肝脏再生[1]。此外,TLR5 还可以诱导抗微生物肽和 CXCL8 的基因表达,通过 IL-1β 基因表达在瘤胃上皮细胞中发挥作用[2]。TLR5 的基因多态性与婴幼儿毛细支气管炎的病毒病因学相关[3],并与溃疡性结肠炎患者中的细胞因子稳态相关[4]。TLR5 还与 COVID-19、急性呼吸窘迫综合征 (ARDS) 和败血症等疾病的发病机制有关[6]。TLR5 的激活可以诱导足细胞凋亡,参与炎症性疾病的发病机制[7]。TLR5 在三阴性乳腺癌中发挥重要作用,可以作为预后和监测指标[8]。TLR5 在囊性纤维化中可以作为抗炎靶点和修饰基因[9]。

综上所述,TLR5 在多种生物学过程中发挥着重要作用,包括肝脏再生、肠道免疫、炎症性疾病和肿瘤发生。TLR5 的研究有助于深入理解其生物学功能和疾病发生机制,为疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Zhang, Wen, Wang, Lei, Sun, Xue-Hua, Yin, Rong-Hua, Yang, Xiao-Ming. 2021. Toll-like receptor 5-mediated signaling enhances liver regeneration in mice. In Military Medical Research, 8, 16. doi:10.1186/s40779-021-00309-4. https://pubmed.ncbi.nlm.nih.gov/33622404/
2. Nishihara, Koki, Suzuki, Yutaka, Haga, Satoshi, Roh, Sanggun. . TLR5 ligand induces the gene expression of antimicrobial peptides and CXCL8 through IL-1β gene expression in cultured rumen epithelial cells. In Animal science journal = Nihon chikusan Gakkaiho, 95, e13972. doi:10.1111/asj.13972. https://pubmed.ncbi.nlm.nih.gov/38923622/
3. Törmänen, Sari, Teräsjärvi, Johanna, Lauhkonen, Eero, Nuolivirta, Kirsi, He, Qiushui. 2018. TLR5 rs5744174 gene polymorphism is associated with the virus etiology of infant bronchiolitis but not with post-bronchiolitis asthma. In Health science reports, 1, e38. doi:10.1002/hsr2.38. https://pubmed.ncbi.nlm.nih.gov/30623075/
4. Meena, Naresh Kumar, Ahuja, Vineet, Meena, Kusumlata, Paul, Jaishree. 2015. Association of TLR5 gene polymorphisms in ulcerative colitis patients of north India and their role in cytokine homeostasis. In PloS one, 10, e0120697. doi:10.1371/journal.pone.0120697. https://pubmed.ncbi.nlm.nih.gov/25789623/
5. Feng, Shuyan, Zhang, Chi, Chen, Shanshan, Chao, Guanqun, Zhang, Shuo. 2023. TLR5 Signaling in the Regulation of Intestinal Mucosal Immunity. In Journal of inflammation research, 16, 2491-2501. doi:10.2147/JIR.S407521. https://pubmed.ncbi.nlm.nih.gov/37337514/
6. Li, Peiyu, Li, Tao, Zhang, Zhiming, Li, Zhen, Li, Zhiwang. 2023. Bioinformatics and system biology approach to identify the influences among COVID-19, ARDS and sepsis. In Frontiers in immunology, 14, 1152186. doi:10.3389/fimmu.2023.1152186. https://pubmed.ncbi.nlm.nih.gov/37261353/
7. Lin, Xu, Huang, Haiting, You, Yanwu, Tan, Junhua, Wang, Jie. 2016. Activation of TLR5 induces podocyte apoptosis. In Cell biochemistry and function, 34, 63-8. doi:10.1002/cbf.3165. https://pubmed.ncbi.nlm.nih.gov/26914743/
8. Shi, Dai, Zhao, Shanshan, Jiang, Wen, Liang, Ting, Hou, Guihua. 2019. TLR5: A prognostic and monitoring indicator for triple-negative breast cancer. In Cell death & disease, 10, 954. doi:10.1038/s41419-019-2187-8. https://pubmed.ncbi.nlm.nih.gov/31852883/
9. Blohmke, Christoph J, Park, Julie, Hirschfeld, Aaron F, Daley, Denise, Turvey, Stuart E. 2010. TLR5 as an anti-inflammatory target and modifier gene in cystic fibrosis. In Journal of immunology (Baltimore, Md. : 1950), 185, 7731-8. doi:10.4049/jimmunol.1001513. https://pubmed.ncbi.nlm.nih.gov/21068401/