MGI:1931526Homozygotes for targeted null mutations are normal, but Hist1h1c/Hist1h1e double knockout males are significantly smaller than normal. The Hist1h1c/Hist1h1e/Hist1h1d triple knockout is lethal by embryonic day 12.5, and heterozygotes are underrepresented.
1. Yusufova, Nevin, Kloetgen, Andreas, Teater, Matt, Cesarman, Ethel, Melnick, Ari M. 2020. Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture. In Nature, 589, 299-305. doi:10.1038/s41586-020-3017-y. https://pubmed.ncbi.nlm.nih.gov/33299181/