Foxr2-flox 基因敲除小鼠

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产品名称

Foxr2-flox 基因敲除小鼠

产品编号

S-CKO-11335

品系全称

C57BL/6JCya-Foxr2em1flox/Cya

品系背景

C57BL/6JCya

品系编号

CKOCMP-436240-Foxr2-B6J-VA

品系状态

使用本品系发表的文献需注明: Foxr2-flox 基因敲除小鼠 mice (Strain S-CKO-11335) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
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小计:
询价
cKO小鼠库模型

基本信息

基因研究概述

质控标准

基因
基因全称
forkhead box R2
基因别称
EG436240,Foxn6
染色体号
Chr X (Mouse)
转录本 ID
NCBI: NM_001034894.3 | Ensembl: ENSMUST00000096265
修饰方式
条件性基因敲除
靶向范围
Exon 4
敲除长度
~1179 bp
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
FOXR2,也称为Forkhead Box R2,是一种属于FOX基因家族的转录因子。FOXR2编码的转录因子在多种生物学过程中发挥重要作用,包括发育、器官生成、代谢和免疫调节以及细胞稳态[4]。FOXR2基因的表达在正常情况下受到严格的调控,主要在睾丸中表达[5]。然而,近年来,越来越多的研究表明,FOXR2在多种癌症中异常表达,并且与肿瘤的发生和发展密切相关[1,2,3,4,5,6,7,8]。

FOXR2的异常表达与多种癌症的发生和发展密切相关。研究表明,FOXR2在卵巢癌中表达上调,并且与上皮-间质转化(EMT)相关标记物的表达水平相关[2]。此外,FOXR2在儿童和成人癌症中也表现出异常表达,包括神经母细胞瘤、脑肿瘤和髓母细胞瘤等[4,6,9,10]。FOXR2的异常表达与肿瘤的生长、转移和耐药性等密切相关[4,7,8]。

FOXR2的异常表达与肿瘤的发生和发展密切相关,并且与多种癌症的预后不良相关。FOXR2在卵巢癌、神经母细胞瘤、脑肿瘤和髓母细胞瘤等癌症中表达上调,并且与肿瘤的生长、转移和耐药性等密切相关。FOXR2的异常表达可能是肿瘤发生和发展的重要驱动因素之一。

参考文献:
1. Katoh, Masuko, Katoh, Masaru. . Human FOX gene family (Review). In International journal of oncology, 25, 1495-500. doi:. https://pubmed.ncbi.nlm.nih.gov/15492844/
2. Asadollahi, Samira, Mazaheri, Mahta Naeini, Karimi-Zarchi, Mojgan. . The Relationship of FOXR2 Gene Expression Profile with Epithelial-Mesenchymal Transition Related Markers in Epithelial Ovarian Cancer. In Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti, 33, 201-207. doi:10.14735/amko2020201. https://pubmed.ncbi.nlm.nih.gov/32683876/
3. Liu, Anthony P Y, Northcott, Paul A. . Pursuing FOXR2-Driven Oncogenesis. In Cancer research, 82, 2977-2979. doi:10.1158/0008-5472.CAN-22-2259. https://pubmed.ncbi.nlm.nih.gov/36052493/
4. Gharbaran, Rajendra. 2023. Insights into the molecular roles of FOXR2 in the pathology of primary pediatric brain tumors. In Critical reviews in oncology/hematology, 192, 104188. doi:10.1016/j.critrevonc.2023.104188. https://pubmed.ncbi.nlm.nih.gov/37879492/
5. Tsai, Jessica W, Cejas, Paloma, Wang, Dayle K, Bandopadhayay, Pratiti, Phoenix, Timothy N. . FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits. In Cancer research, 82, 2980-3001. doi:10.1158/0008-5472.CAN-22-0671. https://pubmed.ncbi.nlm.nih.gov/35802025/
6. Sturm, Dominik, Orr, Brent A, Toprak, Umut H, Korshunov, Andrey, Kool, Marcel. . New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs. In Cell, 164, 1060-1072. doi:10.1016/j.cell.2016.01.015. https://pubmed.ncbi.nlm.nih.gov/26919435/
7. Schmitt-Hoffner, Felix, van Rijn, Sjoerd, Toprak, Umut H, Westermann, Frank, Kool, Marcel. 2021. FOXR2 Stabilizes MYCN Protein and Identifies Non-MYCN-Amplified Neuroblastoma Patients With Unfavorable Outcome. In Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 39, 3217-3228. doi:10.1200/JCO.20.02540. https://pubmed.ncbi.nlm.nih.gov/34110923/
8. Yang, Piao, Sheykhhasan, Mohsen, Heidari, Reza, Dirbaziyan, Ashkan, Al-Musawi, Sharafaldin. 2025. FOXR2 in cancer development: emerging player and therapeutic opportunities. In Oncology research, 33, 283-300. doi:10.32604/or.2024.052939. https://pubmed.ncbi.nlm.nih.gov/39866234/
9. Jessa, Selin, De Cola, Antonella, Chandarana, Bhavyaa, Jabado, Nada, Kleinman, Claudia L. . FOXR2 Targets LHX6+/DLX+ Neural Lineages to Drive Central Nervous System Neuroblastoma. In Cancer research, 85, 231-250. doi:10.1158/0008-5472.CAN-24-2248. https://pubmed.ncbi.nlm.nih.gov/39495206/
10. Koso, Hideto, Tsuhako, Asano, Lyons, Eli, Copeland, Neal G, Watanabe, Sumiko. 2014. Identification of FoxR2 as an oncogene in medulloblastoma. In Cancer research, 74, 2351-61. doi:10.1158/0008-5472.CAN-13-1523. https://pubmed.ncbi.nlm.nih.gov/24599127/