Timm8a1-flox 基因敲除小鼠

1. Song, Pingping, Guan, Yuqing, Chen, Xia, Pan, Suyue, Hu, Yafang. 2020. Frameshift mutation of Timm8a1 gene in mouse leads to an abnormal mitochondrial structure in the brain, correlating with hearing and memory impairment. In Journal of medical genetics, 58, 619-627. doi:10.1136/jmedgenet-2020-106925. https://pubmed.ncbi.nlm.nih.gov/32820032/

2. Ouattara, Niemtiah, Chen, Zirui, Huang, Yihua, Pan, Suyue, Hu, Yafang. 2022. Reduced mitochondrial size in hippocampus and psychiatric behavioral changes in the mutant mice with homologous mutation of Timm8a1-I23fs49X. In Frontiers in cellular neuroscience, 16, 972964. doi:10.3389/fncel.2022.972964. https://pubmed.ncbi.nlm.nih.gov/36090790/

3. Zheng, Jinxuan, Yu, Rongcheng, Tang, Yiqi, Wu, Liping, Cao, Yang. 2023. Cdc42 deletion yielded enamel defects by disrupting mitochondria and producing reactive oxygen species in dental epithelium. In Genes & diseases, 11, 101194. doi:10.1016/j.gendis.2023.101194. https://pubmed.ncbi.nlm.nih.gov/39022131/