智鼠故事 
Fto-flox 基因敲除小鼠
复苏/繁育服务
产品名称
Fto-flox 基因敲除小鼠
产品编号
S-CKO-09550
品系全称
C57BL/6NCya-Ftoem1flox/Cya
品系背景
C57BL/6NCya
品系编号
CKOCMP-26383-Fto-B6N-VA
品系状态
使用本品系发表的文献需注明： Fto-flox 基因敲除小鼠 mice (Strain S-CKO-09550) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
基因
基因全称
fat mass and obesity associated
基因别称
mKIAA1752
染色体号
Chr 8 (Mouse)
NCBI ID
转录本 ID
NCBI: NM_011936 | Ensembl: ENSMUST00000069718
修饰方式
条件性基因敲除
靶向范围
Exon 3
敲除长度
~1.5 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成，建议您在购买前查询最新的数据库和相关文献，以获取最准确的表型信息。
表型提示
MGI:1347093Mice homozygous for an ENU-induced or targeted knock-out allele exhibit decreased body weight, adipose tissue, and body fat and increased metabolism, serum lipids, and serum glucagon that may be gender and diet dependent.
发表文献
Frontiers in Immunology
2025-06-25
FTO O-GlcNAcylation promotes TRIM21-mediated FTO ubiquitination degradation to sustain the negative feedback control of macrophage inflammation
Experimental & Molecular Medicine
2024-10-02
FTO-mediated SMAD2 m6A modification protects cartilage against Osteoarthritis
Ecotoxicology and Environmental Safety
2024-02-29
Oxidative stress-mediated activation of FTO exacerbates impairment of the epithelial barrier by up-regulating IKBKB via N6-methyladenosine-dependent mRNA stability in asthmatic mice exposed to PM2.5
The Journal of Nutritional Biochemistry
2023-10-29
Hypothalamic FTO promotes high-fat diet-induced leptin resistance in mice through increasing CX3CL1 expression
1
发表文献
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