Tnfsf13b-flox 基因敲除小鼠

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产品名称

Tnfsf13b-flox 基因敲除小鼠

产品编号

S-CKO-08322

品系全称

C57BL/6JCya-Tnfsf13bem1flox/Cya

品系背景

C57BL/6JCya

品系编号

CKOCMP-24099-Tnfsf13b-B6J-VA

品系状态

使用本品系发表的文献需注明: Tnfsf13b-flox 基因敲除小鼠 mice (Strain S-CKO-08322) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
cKO小鼠库模型
NF-κB信号通路

基本信息

基因研究概述

质控标准

基因
基因全称
tumor necrosis factor (ligand) superfamily, member 13b
基因别称
BAFF,BLyS,D8Ertd387e,TALL-1,TALL1,THANK,TNFSF20,Tnlg7a,zTNF4
染色体号
Chr 8 (Mouse)
转录本 ID
NCBI: NM_033622 | Ensembl: ENSMUST00000207792
修饰方式
条件性基因敲除
靶向范围
Exon 1~2
敲除长度
~2.6 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:1344376Homozygous null mice have reduced number of B cells and reduced levels of immunoglobulins.
TNFSF13B,也称为B细胞活化因子(BAFF),是一种属于肿瘤坏死因子超家族的细胞因子。BAFF在B细胞的发育、成熟和存活中发挥重要作用,它通过与B细胞上的受体结合,促进B细胞的存活、增殖和分化。此外,BAFF还参与调节免疫系统的平衡,影响自身免疫性疾病的发生发展。BAFF的异常表达或功能障碍与多种自身免疫性疾病,如系统性红斑狼疮(SLE)、类风湿性关节炎(RA)和干燥综合征(SS)等的发生发展密切相关[1][2][3][4][5][6][7][8][9][10]。

TNFSF13B基因编码BAFF蛋白,该基因的突变或多态性可能影响BAFF的表达和功能,进而影响疾病的发生和发展。例如,研究发现,TNFSF13B基因的rs9514828多态性与根尖周炎的易感性相关,其中TT基因型和T等位基因与根尖周炎的易感性增加相关[1]。此外,TNFSF13B基因的rs9514828多态性还与系统性红斑狼疮的疾病活动性相关,rs9514828 T等位基因携带者表现出更高的BAFF mRNA表达和血清sBAFF水平,且与疾病的活性、肾脏和血液系统受累相关[9]。在类风湿性关节炎患者中,TNFSF13B mRNA水平升高,rs9514828 (-871 C>T) 多态性与基因表达增加相关[10]。

TNFSF13B基因的突变或多态性还可能与其他疾病的发生发展相关。例如,研究发现,TNFSF13B基因的高表达与肾透明细胞癌的预后不良相关,TNFSF13B可能成为肾透明细胞癌的潜在生物标志物或治疗靶点[2]。此外,TNFSF13B基因的rs9514828多态性与干燥综合征的易感性相关,其中rs9514828 T等位基因与干燥综合征的易感性增加相关[3]。

综上所述,TNFSF13B基因编码的BAFF蛋白在B细胞的发育、成熟和存活中发挥重要作用,其表达和功能的异常与多种自身免疫性疾病的发生发展密切相关。TNFSF13B基因的突变或多态性可能影响BAFF的表达和功能,进而影响疾病的发生和发展。因此,研究TNFSF13B基因及其编码的BAFF蛋白在疾病发生发展中的作用,有助于深入理解自身免疫性疾病的发病机制,为疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Cruz, Alvaro, Gascón, Luis Gerardo, Palafox-Sánchez, Claudia Azucena, Mejía-Flores, Rocío, Salazar-Camarena, Diana Celeste. 2022. TNFSF13B rs9514828 gene polymorphism and soluble B cell activating factor levels: Association with apical periodontitis. In International endodontic journal, 56, 419-431. doi:10.1111/iej.13879. https://pubmed.ncbi.nlm.nih.gov/36508294/
2. Jiang, Mingzhe, Lin, Jiaxing, Xing, Haotian, Yu, Meng, Zhu, Yuyan. 2020. Microenvironment-related gene TNFSF13B predicts poor prognosis in kidney renal clear cell carcinoma. In PeerJ, 8, e9453. doi:10.7717/peerj.9453. https://pubmed.ncbi.nlm.nih.gov/32655996/
3. Zheng, Anhao, Hu, Naiwen, Xu, Jing, Bai, Yanyan, Sun, Hongsheng. . Associations between TNFSF13B polymorphisms and primary Sjögren's syndrome susceptibility in primary Sjögren's syndrome patients: A meta-analysis. In Immunity, inflammation and disease, 11, e1103. doi:10.1002/iid3.1103. https://pubmed.ncbi.nlm.nih.gov/38156381/
4. Consiglio, Arianna, Nuzziello, Nicoletta, Liguori, Maria. . Dysregulation of Gene Expressions in Multiple Sclerosis: TNFSF13B and Other Candidate Genes. In Journal of integrative neuroscience, 22, 4. doi:10.31083/j.jin2201004. https://pubmed.ncbi.nlm.nih.gov/36722235/
5. Smulski, Cristian R, Eibel, Hermann. 2018. BAFF and BAFF-Receptor in B Cell Selection and Survival. In Frontiers in immunology, 9, 2285. doi:10.3389/fimmu.2018.02285. https://pubmed.ncbi.nlm.nih.gov/30349534/
6. Wang, Yingyu, Huang, Zhongzhou, Xiao, Yu, Wan, Weiguo, Yang, Xue. 2022. The shared biomarkers and pathways of systemic lupus erythematosus and metabolic syndrome analyzed by bioinformatics combining machine learning algorithm and single-cell sequencing analysis. In Frontiers in immunology, 13, 1015882. doi:10.3389/fimmu.2022.1015882. https://pubmed.ncbi.nlm.nih.gov/36341378/
7. Lv, Min, Cai, Yuanzhen, Hou, Weikun, Zhang, Weisong, Liu, Lin. 2024. The C5AR1/TNFSF13B axis alleviates osteoarthritis by activating the PI3K/Akt/GSK3β/Nrf2/HO-1 pathway to inhibit ferroptosis. In Experimental cell research, 441, 114195. doi:10.1016/j.yexcr.2024.114195. https://pubmed.ncbi.nlm.nih.gov/39098466/
8. Binvignat, Marie, Miao, Brenda Y, Wibrand, Camilla, Nakamura, Mary C, Sirota, Marina. 2024. Single-cell RNA-Seq analysis reveals cell subsets and gene signatures associated with rheumatoid arthritis disease activity. In JCI insight, 9, . doi:10.1172/jci.insight.178499. https://pubmed.ncbi.nlm.nih.gov/38954480/
9. Marín-Rosales, M, Cruz, A, Salazar-Camarena, D C, Orozco-Barocio, G, Palafox-Sánchez, C A. 2019. High BAFF expression associated with active disease in systemic lupus erythematosus and relationship with rs9514828C>T polymorphism in TNFSF13B gene. In Clinical and experimental medicine, 19, 183-190. doi:10.1007/s10238-019-00549-8. https://pubmed.ncbi.nlm.nih.gov/30747361/
10. Santillán-López, Enrique, Muñoz-Valle, José Francisco, Oregon-Romero, Edith, Cerpa-Cruz, Sergio, Palafox-Sánchez, Claudia Azucena. 2022. Analysis of TNFSF13B polymorphisms and BAFF expression in rheumatoid arthritis and primary Sjögren's syndrome patients. In Molecular genetics & genomic medicine, 10, e1950. doi:10.1002/mgg3.1950. https://pubmed.ncbi.nlm.nih.gov/35411715/