Insig1-flox 基因敲除小鼠

1. Xu, Daqian, Wang, Zheng, Xia, Yan, Hung, Mien-Chie, Lu, Zhimin. 2020. The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis. In Nature, 580, 530-535. doi:10.1038/s41586-020-2183-2. https://pubmed.ncbi.nlm.nih.gov/32322062/

2. Azzu, Vian, Vacca, Michele, Kamzolas, Ioannis, Allison, Michael E D, Vidal-Puig, Antonio. 2021. Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression. In Molecular metabolism, 48, 101210. doi:10.1016/j.molmet.2021.101210. https://pubmed.ncbi.nlm.nih.gov/33722690/

3. Li, Shumin, Qin, Jun, Zhao, Yingying, Huang, Songming, Yu, Xiaowen. 2024. Tubular insulin-induced gene 1 deficiency promotes NAD+ consumption and exacerbates kidney fibrosis. In EMBO molecular medicine, 16, 1675-1703. doi:10.1038/s44321-024-00081-7. https://pubmed.ncbi.nlm.nih.gov/38806641/

4. Xiong, Li, Liu, Hua-Shan, Zhou, Chi, Kang, Liang, Liang, Zhen-Xing. 2023. A novel protein encoded by circINSIG1 reprograms cholesterol metabolism by promoting the ubiquitin-dependent degradation of INSIG1 in colorectal cancer. In Molecular cancer, 22, 72. doi:10.1186/s12943-023-01773-3. https://pubmed.ncbi.nlm.nih.gov/37087475/