MGI:106679Defects in neurulation and forebrain development have been identified in both targeted and ENU induced homozygous mutants. Death occurs perinatally in the targeted mouse and during midgestation in the ENU mouse. Mice homozygous for a knock-down allele exhibit cognitive and social behavior defects. A critical mutation in the last zinc finger domain results in multiple isomerism-related and other malformations in the embryonic brain