Gpbar1-flox 基因敲除小鼠

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2. Fiorucci, Stefano, Carino, Adriana, Baldoni, Monia, Distrutti, Eleonora, Biagioli, Michele. 2020. Bile Acid Signaling in Inflammatory Bowel Diseases. In Digestive diseases and sciences, 66, 674-693. doi:10.1007/s10620-020-06715-3. https://pubmed.ncbi.nlm.nih.gov/33289902/

3. Reich, Maria, Spomer, Lina, Klindt, Caroline, Heikenwalder, Mathias, Keitel, Verena. 2021. Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis. In Journal of hepatology, 75, 634-646. doi:10.1016/j.jhep.2021.03.029. https://pubmed.ncbi.nlm.nih.gov/33872692/

4. Biagioli, Michele, Di Giorgio, Cristina, Morretta, Elva, Zampella, Angela, Fiorucci, Stefano. 2024. Development of dual GPBAR1 agonist and RORγt inverse agonist for the treatment of inflammatory bowel diseases. In Pharmacological research, 208, 107403. doi:10.1016/j.phrs.2024.107403. https://pubmed.ncbi.nlm.nih.gov/39265668/

5. Sorrentino, Giovanni, Perino, Alessia, Yildiz, Ece, Pellicciari, Roberto, Schoonjans, Kristina. 2020. Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration. In Gastroenterology, 159, 956-968.e8. doi:10.1053/j.gastro.2020.05.067. https://pubmed.ncbi.nlm.nih.gov/32485177/

6. Biagioli, Michele, Marchianò, Silvia, Di Giorgio, Cristina, Cirino, Giuseppe, Fiorucci, Stefano. 2023. Activation of GPBAR1 attenuates vascular inflammation and atherosclerosis in a mouse model of NAFLD-related cardiovascular disease. In Biochemical pharmacology, 218, 115900. doi:10.1016/j.bcp.2023.115900. https://pubmed.ncbi.nlm.nih.gov/37926268/