Ybx1-flox 基因敲除小鼠

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产品名称

Ybx1-flox 基因敲除小鼠

产品编号

S-CKO-06892

品系全称

C57BL/6JCya-Ybx1em1flox/Cya

品系背景

C57BL/6JCya

品系编号

CKOCMP-22608-Ybx1-B6J-VA

品系状态

使用本品系发表的文献需注明: Ybx1-flox 基因敲除小鼠 mice (Strain S-CKO-06892) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
cKO小鼠库模型

基本信息

基因研究概述

质控标准

基因
基因全称
Y box protein 1
基因别称
1700102N10Rik,EF1A,MSY1,Nsep1,YB-1,dbpB,mYB-1a
染色体号
Chr 4 (Mouse)
转录本 ID
NCBI: NM_011732 | Ensembl: ENSMUST00000079644
修饰方式
条件性基因敲除
靶向范围
Exon 4~6
敲除长度
~2.1 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:99146Homozygous null mice exhibit embryonic and perinatal lethality and are severely growth retarded. Some mice exhibit craniofacial defects and respiratory failure. MEFs are more sensitive to oxidative stress resulting in premature senescence.
YBX1,也称为Y-box结合蛋白1,是一种重要的RNA结合蛋白(RBP)。RNA结合蛋白是一类能够与RNA分子结合的蛋白质,它们在转录和翻译的调控中发挥着关键作用。YBX1在多种生物学过程中发挥作用,包括细胞分化、发育、代谢和疾病发生。

YBX1在多种疾病中发挥重要作用,包括白血病、骨老化、食管鳞状细胞癌、肝癌、卵巢癌、胃癌和乳腺癌。YBX1通过多种机制影响这些疾病的发生和发展,包括调节mRNA稳定性、影响RNA剪接和翻译、以及影响细胞凋亡和细胞周期等。

YBX1在白血病细胞中表达上调,对于维持白血病细胞存活至关重要。YBX1通过与胰岛素样生长因子2信使RNA(mRNA)结合蛋白(IGF2BPs)相互作用,稳定m6A标记的RNA,从而影响凋亡相关基因的表达,导致白血病细胞凋亡和分化受阻[1]。YBX1在骨髓基质细胞(BMSCs)中的表达随着年龄的增长而下降,YBX1缺乏导致BMSCs分化障碍和细胞衰老,进而导致骨丢失。YBX1的过表达可以刺激骨形成,为治疗与年龄相关的骨质疏松症提供了潜在的靶点[2]。YBX1在JAK2突变型白血病中发挥作用,YBX1的失活可以增强细胞对JAK抑制剂的敏感性,并导致RNA剪接异常和ERK信号通路的破坏,从而抑制白血病细胞生长[3]。

YBX1在食管鳞状细胞癌(ESCC)中表达上调,YBX1通过稳定SMOX mRNA并激活mTORC1信号通路,促进ESCC细胞增殖和转移[4]。YBX1通过circRNA-YBX1介导的液-液相分离抑制TPM4的表达,进而抑制肝癌细胞的转移[5]。YBX1在卵巢癌中表达上调,YBX1通过识别CHD3 mRNA中的m5C修饰并维持其稳定性,增强同源重组修复能力,从而提高卵巢癌细胞对顺铂的耐药性[6]。YBX1在胃癌中通过抑制PANoptosis,增强胃癌细胞对奥沙利铂的耐药性。YBX1与PPM1B和USP10相互作用,影响YBX1的磷酸化和泛素化,进而影响PANoptosis和奥沙利铂敏感性[7]。

YBX1在乳腺癌中表达上调,YBX1通过下调CORO1C的表达,抑制乳腺癌细胞的迁移和侵袭[8]。YBX1在胰腺癌中通过YBX1-LRP1-β-catenin-RRM1轴促进胰腺癌的进展和吉西他滨耐药性。YBX1抑制剂SU056与吉西他滨联合使用可以有效地克服吉西他滨耐药性[9]。YBX1在TNBC中与KMT2D相互作用,共同激活c-Myc和SENP1的表达,促进TNBC的进展和转移[10]。

综上所述,YBX1是一种重要的RNA结合蛋白,参与调控RNA的稳定性和功能,影响基因表达和生物学过程。YBX1在多种疾病中发挥重要作用,包括白血病、骨老化、食管鳞状细胞癌、肝癌、卵巢癌、胃癌和乳腺癌。YBX1的研究有助于深入理解RNA表观遗传修饰的生物学功能和疾病发生机制,为疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Feng, Mengdie, Xie, Xueqin, Han, Guoqiang, Chen, Jianjun, Zhang, Haojian. . YBX1 is required for maintaining myeloid leukemia cell survival by regulating BCL2 stability in an m6A-dependent manner. In Blood, 138, 71-85. doi:10.1182/blood.2020009676. https://pubmed.ncbi.nlm.nih.gov/33763698/
2. Xiao, Ye, Cai, Guang-Ping, Feng, Xu, Zheng, Yong-Jun, Yang, Mi. 2023. Splicing factor YBX1 regulates bone marrow stromal cell fate during aging. In The EMBO journal, 42, e111762. doi:10.15252/embj.2022111762. https://pubmed.ncbi.nlm.nih.gov/36943004/
3. Jayavelu, Ashok Kumar, Schnöder, Tina M, Perner, Florian, Mann, Matthias, Heidel, Florian H. 2020. Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms. In Nature, 588, 157-163. doi:10.1038/s41586-020-2968-3. https://pubmed.ncbi.nlm.nih.gov/33239784/
4. Liu, Liwen, Chen, Yu, Zhang, Tao, Xue, Wenhua, Sun, Ranran. 2024. [Not Available]. In Advanced science (Weinheim, Baden-Wurttemberg, Germany), 11, e2302379. doi:10.1002/advs.202302379. https://pubmed.ncbi.nlm.nih.gov/38566431/
5. Liu, Boqiang, Shen, Hao, He, Jing, Shi, Liang, Cai, Xiujun. 2023. Cytoskeleton remodeling mediated by circRNA-YBX1 phase separation suppresses the metastasis of liver cancer. In Proceedings of the National Academy of Sciences of the United States of America, 120, e2220296120. doi:10.1073/pnas.2220296120. https://pubmed.ncbi.nlm.nih.gov/37459535/
6. Meng, Huangyang, Miao, Huixian, Zhang, Yashuang, Zhang, Lin, Cheng, Wenjun. 2024. YBX1 promotes homologous recombination and resistance to platinum-induced stress in ovarian cancer by recognizing m5C modification. In Cancer letters, 597, 217064. doi:10.1016/j.canlet.2024.217064. https://pubmed.ncbi.nlm.nih.gov/38880223/
7. Lin, Chunlin, Lin, Penghang, Yao, Hengxin, Ye, Jianxin, Zhu, Guangwei. 2024. Modulation of YBX1-mediated PANoptosis inhibition by PPM1B and USP10 confers chemoresistance to oxaliplatin in gastric cancer. In Cancer letters, 587, 216712. doi:10.1016/j.canlet.2024.216712. https://pubmed.ncbi.nlm.nih.gov/38364962/
8. Lim, Jia Pei, Shyamasundar, Sukanya, Gunaratne, Jayantha, Matsumoto, Ken, Bay, Boon Huat. 2017. YBX1 gene silencing inhibits migratory and invasive potential via CORO1C in breast cancer in vitro. In BMC cancer, 17, 201. doi:10.1186/s12885-017-3187-7. https://pubmed.ncbi.nlm.nih.gov/28302118/
9. Li, Borui, Xing, Faliang, Wang, Jingyi, Qin, Yi, Li, Zheng. 2024. YBX1 as a therapeutic target to suppress the LRP1-β-catenin-RRM1 axis and overcome gemcitabine resistance in pancreatic cancer. In Cancer letters, 602, 217197. doi:10.1016/j.canlet.2024.217197. https://pubmed.ncbi.nlm.nih.gov/39216548/
10. Yao, Bing, Xing, Mengying, Zeng, Xiangwei, Zhao, Quan, Ma, Changyan. . KMT2D-mediated H3K4me1 recruits YBX1 to facilitate triple-negative breast cancer progression through epigenetic activation of c-Myc. In Clinical and translational medicine, 14, e1753. doi:10.1002/ctm2.1753. https://pubmed.ncbi.nlm.nih.gov/38967349/