Thoc1-flox 基因敲除小鼠

1. Yin, Shenmin, Goodrich, David W. . Combination gene therapy with p53 and Thoc1/p84 is more effective than either single agent in an animal model of human pancreatic adenocarcinoma. In International journal of oncology, 28, 781-5. doi:. https://pubmed.ncbi.nlm.nih.gov/16465385/

2. Wang, Xiaoling, Chinnam, Meenalakshmi, Wang, Jianmin, Moens, Peter, Goodrich, David W. 2009. Thoc1 deficiency compromises gene expression necessary for normal testis development in the mouse. In Molecular and cellular biology, 29, 2794-803. doi:10.1128/MCB.01633-08. https://pubmed.ncbi.nlm.nih.gov/19307311/

3. Wang, Xiaoling, Li, Yanping, Zhang, Xiaojing, Goodrich, David W. . An allelic series for studying the mouse Thoc1 gene. In Genesis (New York, N.Y. : 2000), 45, 32-7. doi:. https://pubmed.ncbi.nlm.nih.gov/17211872/

4. Chinnam, Meenalakshmi, Wang, Yanqing, Zhang, Xiaojing, Mohler, James L, Goodrich, David W. 2014. The Thoc1 ribonucleoprotein and prostate cancer progression. In Journal of the National Cancer Institute, 106, . doi:10.1093/jnci/dju306. https://pubmed.ncbi.nlm.nih.gov/25296641/

5. Cai, Shijiao, Bai, Yunpeng, Wang, Huan, Yang, Cheng, Sun, Tao. 2020. Knockdown of THOC1 reduces the proliferation of hepatocellular carcinoma and increases the sensitivity to cisplatin. In Journal of experimental & clinical cancer research : CR, 39, 135. doi:10.1186/s13046-020-01634-7. https://pubmed.ncbi.nlm.nih.gov/32669125/

6. Wang, Xiaoling, Chang, Yanjie, Li, Yanping, Zhang, Xiaojing, Goodrich, David W. . Thoc1/Hpr1/p84 is essential for early embryonic development in the mouse. In Molecular and cellular biology, 26, 4362-7. doi:. https://pubmed.ncbi.nlm.nih.gov/16705185/

7. Pitzonka, Laura, Ullas, Sumana, Chinnam, Meenalakshmi, Evans, Sharon, Goodrich, David W. 2014. The Thoc1 encoded ribonucleoprotein is required for myeloid progenitor cell homeostasis in the adult mouse. In PloS one, 9, e97628. doi:10.1371/journal.pone.0097628. https://pubmed.ncbi.nlm.nih.gov/24830368/

8. Zhang, Luping, Gao, Yu, Zhang, Ru, Wu, Hao, Liu, Dong. 2020. THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis. In PLoS genetics, 16, e1008953. doi:10.1371/journal.pgen.1008953. https://pubmed.ncbi.nlm.nih.gov/32776944/

9. Song, Fei, Fan, Chuandong, Wang, Xinjiang, Goodrich, David W. 2013. The Thoc1 encoded ribonucleoprotein is a substrate for the NEDD4-1 E3 ubiquitin protein ligase. In PloS one, 8, e57995. doi:10.1371/journal.pone.0057995. https://pubmed.ncbi.nlm.nih.gov/23460917/

10. Chou, Yi-Ju, Lin, Ching-Cheng, Hsu, Ya-Chi, Lin, Chao-Hsiung, Fu, Shu-Ling. 2022. Andrographolide suppresses the malignancy of triple-negative breast cancer by reducing THOC1-promoted cancer stem cell characteristics. In Biochemical pharmacology, 206, 115327. doi:10.1016/j.bcp.2022.115327. https://pubmed.ncbi.nlm.nih.gov/36330949/