MGI:1328355Homozygous null mice typically exhibit impaired glucose tolerance, decreased body weight, and abnormal behavior associated with increased sensitivity to stress. Mice homozygous for a knock-out allele exhibit reduced male fertility associated with alterations in sperm morphology and a reduced number of spermatogenic cells. Homozygosity for the p.E864K mutation leads to vestibular defects and early onset deafness. Homozygous KO affects cochlear hair cells and leads to late onset hearing deficits.