Kdm6b-flox 基因敲除小鼠

1. Jiang, Yuhang, Li, Fengfeng, Gao, Bowen, Liu, Sanhong, Shen, Huiyong. 2021. KDM6B-mediated histone demethylation of LDHA promotes lung metastasis of osteosarcoma. In Theranostics, 11, 3868-3881. doi:10.7150/thno.53347. https://pubmed.ncbi.nlm.nih.gov/33664867/

2. Wijayatunge, Ranjula, Liu, Fang, Shpargel, Karl B, Magnuson, Terry, West, Anne E. 2017. The histone demethylase Kdm6b regulates a mature gene expression program in differentiating cerebellar granule neurons. In Molecular and cellular neurosciences, 87, 4-17. doi:10.1016/j.mcn.2017.11.005. https://pubmed.ncbi.nlm.nih.gov/29254825/

3. Goswami, Sangeeta, Raychaudhuri, Deblina, Singh, Pratishtha, Basu, Sreyashi, Sharma, Padmanee. 2023. Myeloid-specific KDM6B inhibition sensitizes glioblastoma to PD1 blockade. In Nature cancer, 4, 1455-1473. doi:10.1038/s43018-023-00620-0. https://pubmed.ncbi.nlm.nih.gov/37653141/

4. Cao, Zhi, Shi, Xiaolei, Tian, Feng, Chung, Leland W K, Wang, Fubo. 2021. KDM6B is an androgen regulated gene and plays oncogenic roles by demethylating H3K27me3 at cyclin D1 promoter in prostate cancer. In Cell death & disease, 12, 2. doi:10.1038/s41419-020-03354-4. https://pubmed.ncbi.nlm.nih.gov/33414463/

5. Ge, Chutian, Ye, Jian, Weber, Ceri, Qian, Guoying, Capel, Blanche. . The histone demethylase KDM6B regulates temperature-dependent sex determination in a turtle species. In Science (New York, N.Y.), 360, 645-648. doi:10.1126/science.aap8328. https://pubmed.ncbi.nlm.nih.gov/29748283/