智鼠故事 
Nr1h4-flox 基因敲除小鼠
纯合子现货秒杀
复苏/繁育服务
产品名称
Nr1h4-flox 基因敲除小鼠
产品编号
S-CKO-04890
品系全称
C57BL/6NCya-Nr1h4em1flox/Cya
品系背景
C57BL/6NCya
品系编号
CKOCMP-20186-Nr1h4-B6N-VA
品系状态
使用本品系发表的文献需注明： Nr1h4-flox 基因敲除小鼠 mice (Strain S-CKO-04890) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
基因
基因全称
nuclear receptor subfamily 1, group H, member 4
基因别称
Fxr，HRR1，RIP14，Rxrip14
染色体号
Chr 10 (Mouse)
NCBI ID
转录本 ID
NCBI: NM_001163700 | Ensembl: ENSMUST00000105296
修饰方式
条件性基因敲除
靶向范围
Exon 4
敲除长度
~1.0 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成，建议您在购买前查询最新的数据库和相关文献，以获取最准确的表型信息。
表型提示
MGI:1352464Mice homozygous for knock-out alleles exhibit increased bile salts and abnormal liver morphology and physiology. Mice homozygous for one knock-out allele also exhibit abnormal lipid homeostasis.
发表文献
Nature Communications
2026-04-03
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Cell Host & Microbe
2024-01-16
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Journal of Pineal Research
2023-11-07
Melatonin improves cholestatic liver disease via the gut‐liver axis
1
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