Kdm4b-flox 基因敲除小鼠

1. Duncan, Anna R, Vitobello, Antonio, Collins, Stephan C, Yalcin, Binnaz, Agrawal, Pankaj B. 2020. Heterozygous Variants in KDM4B Lead to Global Developmental Delay and Neuroanatomical Defects. In American journal of human genetics, 107, 1170-1177. doi:10.1016/j.ajhg.2020.11.001. https://pubmed.ncbi.nlm.nih.gov/33232677/

2. Wu, Meng-Jen, Chen, Chih-Jung, Lin, Ting-Yu, Kung, Hsing-Jien, Wang, Wen-Ching. 2021. Targeting KDM4B that coactivates c-Myc-regulated metabolism to suppress tumor growth in castration-resistant prostate cancer. In Theranostics, 11, 7779-7796. doi:10.7150/thno.58729. https://pubmed.ncbi.nlm.nih.gov/34335964/

3. Cheng, Yingduan, Yuan, Quan, Vergnes, Laurent, Reue, Karen, Wang, Cun-Yu. 2018. KDM4B protects against obesity and metabolic dysfunction. In Proceedings of the National Academy of Sciences of the United States of America, 115, E5566-E5575. doi:10.1073/pnas.1721814115. https://pubmed.ncbi.nlm.nih.gov/29844188/

4. Sha, Jianjun, Han, Qing, Chi, Chenfei, Xia, Weiliang, Xue, Wei. 2019. Upregulated KDM4B promotes prostate cancer cell proliferation by activating autophagy. In Journal of cellular physiology, 235, 2129-2138. doi:10.1002/jcp.29117. https://pubmed.ncbi.nlm.nih.gov/31468537/