Prpf8-flox 基因敲除小鼠

1. López-Cánovas, Juan L, Hermán-Sánchez, Natalia, Del Rio-Moreno, Mercedes, Luque, Raúl M, Gahete, Manuel D. 2023. PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating FAK/AKT pathway via fibronectin 1 splicing. In Experimental & molecular medicine, 55, 132-142. doi:10.1038/s12276-022-00917-7. https://pubmed.ncbi.nlm.nih.gov/36609600/

2. O'Grady, Lauren, Schrier Vergano, Samantha A, Hoffman, Trevor L, Sweetser, David A, Gold, Nina B. 2022. Heterozygous variants in PRPF8 are associated with neurodevelopmental disorders. In American journal of medical genetics. Part A, 188, 2750-2759. doi:10.1002/ajmg.a.62772. https://pubmed.ncbi.nlm.nih.gov/35543142/

3. Sun, Yiyang, Zhang, Lingling, Fang, Zhuoqing, Liao, Bing, Jin, Ying. 2023. PRPF8 controls alternative splicing of PIRH2 to modulate the p53 pathway and survival of human ESCs. In Journal of cellular physiology, 238, 1909-1920. doi:10.1002/jcp.31066. https://pubmed.ncbi.nlm.nih.gov/37357506/

4. Cao, Difei, Xue, Jiaying, Huang, Guoqing, An, Jing, An, Weiwei. . The role of splicing factor PRPF8 in breast cancer. In Technology and health care : official journal of the European Society for Engineering and Medicine, 30, 293-301. doi:10.3233/THC-THC228028. https://pubmed.ncbi.nlm.nih.gov/35124606/