Tmc2-flox 基因敲除小鼠

1. Ratzan, Evan M, Lee, John, Madison, Margot A, Géléoc, Gwenaëlle S G, Holt, Jeffrey R. 2024. TMC function, dysfunction, and restoration in mouse vestibular organs. In Frontiers in neurology, 15, 1356614. doi:10.3389/fneur.2024.1356614. https://pubmed.ncbi.nlm.nih.gov/38638308/

2. Asai, Yukako, Pan, Bifeng, Nist-Lund, Carl, Holt, Jeffrey R, Géléoc, Gwenaelle S G. 2018. Transgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1. In Scientific reports, 8, 12124. doi:10.1038/s41598-018-28958-x. https://pubmed.ncbi.nlm.nih.gov/30108254/

3. Nakanishi, Hiroshi, Kurima, Kiyoto, Pan, Bifeng, Holt, Jeffrey R, Griffith, Andrew J. 2018. Tmc2 expression partially restores auditory function in a mouse model of DFNB7/B11 deafness caused by loss of Tmc1 function. In Scientific reports, 8, 12125. doi:10.1038/s41598-018-29709-8. https://pubmed.ncbi.nlm.nih.gov/30108230/

4. Askew, Charles, Rochat, Cylia, Pan, Bifeng, Aebischer, Patrick, Holt, Jeffrey R. . Tmc gene therapy restores auditory function in deaf mice. In Science translational medicine, 7, 295ra108. doi:10.1126/scitranslmed.aab1996. https://pubmed.ncbi.nlm.nih.gov/26157030/