Mertk-flox 基因敲除小鼠

1. Morse, Christina, Tabib, Tracy, Sembrat, John, Rojas, Mauricio, Lafyatis, Robert. 2019. Proliferating SPP1/MERTK-expressing macrophages in idiopathic pulmonary fibrosis. In The European respiratory journal, 54, . doi:10.1183/13993003.02441-2018. https://pubmed.ncbi.nlm.nih.gov/31221805/

2. Pan, Ziyan, El Sharkway, Rasha, Bayoumi, Ali, George, Jacob, Eslam, Mohammed. 2024. Inhibition of MERTK reduces organ fibrosis in mouse models of fibrotic disease. In Science translational medicine, 16, eadj0133. doi:10.1126/scitranslmed.adj0133. https://pubmed.ncbi.nlm.nih.gov/38569018/

3. Wu, Naming, Li, Jun, Li, Lu, Tan, Zheng, Tao, Juan. 2024. MerTK+ macrophages promote melanoma progression and immunotherapy resistance through AhR-ALKAL1 activation. In Science advances, 10, eado8366. doi:10.1126/sciadv.ado8366. https://pubmed.ncbi.nlm.nih.gov/39365866/

4. Zhou, Yi, Fei, Mingjian, Zhang, Gu, Roose-Girma, Merone, Yan, Minhong. 2020. Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP. In Immunity, 52, 357-373.e9. doi:10.1016/j.immuni.2020.01.014. https://pubmed.ncbi.nlm.nih.gov/32049051/

5. Shen, Kimberle, Reichelt, Mike, Kyauk, Roxanne V, Sheng, Morgan, Yuen, Tracy J. . Multiple sclerosis risk gene Mertk is required for microglial activation and subsequent remyelination. In Cell reports, 34, 108835. doi:10.1016/j.celrep.2021.108835. https://pubmed.ncbi.nlm.nih.gov/33691116/

6. LaVail, Matthew M, Yasumura, Douglas, Matthes, Michael T, Deng, Wen-Tao, Vollrath, Douglas. . Gene Therapy for MERTK-Associated Retinal Degenerations. In Advances in experimental medicine and biology, 854, 487-93. doi:10.1007/978-3-319-17121-0_65. https://pubmed.ncbi.nlm.nih.gov/26427450/