Magoh-flox 基因敲除小鼠

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产品名称

Magoh-flox 基因敲除小鼠

产品编号

S-CKO-03631

品系全称

C57BL/6JCya-Magohem1flox/Cya

品系背景

C57BL/6JCya

品系编号

CKOCMP-17149-Magoh-B6J-VA

品系状态

使用本品系发表的文献需注明: Magoh-flox 基因敲除小鼠 mice (Strain S-CKO-03631) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
cKO小鼠库模型

基本信息

基因研究概述

质控标准

基因
基因全称
mago homolog, exon junction complex core component
基因别称
Mago-m,Mos2
染色体号
Chr 4 (Mouse)
转录本 ID
NCBI: NM_001282737 | Ensembl: ENSMUST00000030348
修饰方式
条件性基因敲除
靶向范围
Exon 2
敲除长度
~1.2 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:1330312Homozygous null mutation in this gene is embryonic lethal and heterozygous mice are postnatal lethal with incomplete penetrance with reduced body size and microcephaly.
Magoh,也称为Mago-nashi homolog,是一种在真核生物中普遍存在的蛋白质,是外显子连接复合物(EJC)的核心组成部分。EJC在mRNA代谢中发挥着至关重要的作用,包括mRNA剪接、出核、翻译和NMD(无义介导的mRNA降解)。Magoh蛋白在胚胎发育和正常细胞功能中起着至关重要的作用[1]。Magoh的异源二聚体形成和核定位对其稳定性至关重要[5]。Magoh在多种癌症中表达异常,包括胃癌和低级别胶质瘤,与不良预后相关[2,3]。Magoh在神经系统中也发挥着重要作用,参与皮质中间神经元的生成和存活[7]。Magoh在细胞周期调控中也发挥着作用,影响Cdk活性[4]。Magoh在非脊椎动物的脊索动物中也存在,表明其在神经系统发育和进化中可能发挥着重要作用[6]。

Magoh是一种重要的蛋白质,在mRNA代谢、胚胎发育、正常细胞功能、神经系统发育和细胞周期调控中发挥着重要作用。Magoh在多种癌症中表达异常,与不良预后相关。Magoh的研究有助于深入理解其在各种生物学过程中的作用,为疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Mitra, Rumela, Rehman, Ayushi, Singh, Kusum Kumari, Jaganathan, Bithiah Grace. 2022. Multifaceted roles of MAGOH Proteins. In Molecular biology reports, 50, 1931-1941. doi:10.1007/s11033-022-07904-1. https://pubmed.ncbi.nlm.nih.gov/36396768/
2. Yu, Shanshan, Chen, Cheng, Chen, Ming, Zhu, Xiaohua, Zhou, Donghui. 2024. MAGOH promotes gastric cancer progression via hnRNPA1 expression inhibition-mediated RONΔ160/PI3K/AKT signaling pathway activation. In Journal of experimental & clinical cancer research : CR, 43, 32. doi:10.1186/s13046-024-02946-8. https://pubmed.ncbi.nlm.nih.gov/38268030/
3. Xiao, Feng, Long, Zhenli, Guo, Yun, Huang, Kai, Guo, Hua. 2023. MAGOH is correlated with poor prognosis and is essential for cell proliferation in lower-grade glioma. In Aging, 15, 5713-5733. doi:10.18632/aging.204823. https://pubmed.ncbi.nlm.nih.gov/37390121/
4. Inaki, Makoto, Kato, Dai, Utsugi, Takahiko, Hanaoka, Fumio, Murakami, Yasufumi. 2011. Genetic analyses using a mouse cell cycle mutant identifies magoh as a novel gene involved in Cdk regulation. In Genes to cells : devoted to molecular & cellular mechanisms, 16, 166-78. doi:10.1111/j.1365-2443.2010.01479.x. https://pubmed.ncbi.nlm.nih.gov/21210908/
5. Ma, Qingfeng, Tatsuno, Takanori, Nakamura, Yuka, Ishigaki, Yasuhito. 2019. The stability of Magoh and Y14 depends on their heterodimer formation and nuclear localization. In Biochemical and biophysical research communications, 511, 631-636. doi:10.1016/j.bbrc.2019.02.097. https://pubmed.ncbi.nlm.nih.gov/30826064/
6. Sepe, Rosa Maria, Ghiron, Jung Hee Levialdi, Zucchetti, Ivana, D'Aniello, Salvatore, Sordino, Paolo. 2020. The EJC component Magoh in non-vertebrate chordates. In Development genes and evolution, 230, 295-304. doi:10.1007/s00427-020-00664-7. https://pubmed.ncbi.nlm.nih.gov/32632492/
7. Sheehan, Charles J, McMahon, John J, Serdar, Lucas D, Silver, Debra L. 2020. Dosage-dependent requirements of Magoh for cortical interneuron generation and survival. In Development (Cambridge, England), 147, . doi:10.1242/dev.182295. https://pubmed.ncbi.nlm.nih.gov/31857347/