Kirrel1-flox 基因敲除小鼠

1. Gu, Yuan, Wang, Yu, Sha, Zhao, Lan, Fei, Yu, Fa-Xing. . Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers. In Cell reports, 40, 111296. doi:10.1016/j.celrep.2022.111296. https://pubmed.ncbi.nlm.nih.gov/36044856/

2. Solanki, Ashish K, Widmeier, Eugen, Arif, Ehtesham, Hildebrandt, Friedhelm, Nihalani, Deepak. 2019. Mutations in KIRREL1, a slit diaphragm component, cause steroid-resistant nephrotic syndrome. In Kidney international, 96, 883-889. doi:10.1016/j.kint.2019.06.016. https://pubmed.ncbi.nlm.nih.gov/31472902/

3. Wang, Chao, Feng, Xu, Su, Dan, Hart, Traver, Chen, Junjie. 2022. Integrated screens uncover a cell surface tumor suppressor gene KIRREL involved in Hippo pathway. In Proceedings of the National Academy of Sciences of the United States of America, 119, e2121779119. doi:10.1073/pnas.2121779119. https://pubmed.ncbi.nlm.nih.gov/35704761/

4. Paul, Atanu, Annunziato, Stefano, Lu, Bo, Tchorz, Jan S, Cong, Feng. 2022. Cell adhesion molecule KIRREL1 is a feedback regulator of Hippo signaling recruiting SAV1 to cell-cell contact sites. In Nature communications, 13, 930. doi:10.1038/s41467-022-28567-3. https://pubmed.ncbi.nlm.nih.gov/35177623/