智鼠故事 
C57BL/6JCya-Lmnaem1flox/Cya 条件性基因敲除小鼠
复苏/繁育服务
产品名称
Lmna-flox
产品编号
S-CKO-03406
品系全称
C57BL/6JCya-Lmnaem1flox/Cya
品系背景
C57BL/6JCya
品系编号
CKOCMP-16905-Lmna-B6J-VA
品系状态
使用本品系发表的文献需注明： Lmna-flox mice (Strain S-CKO-03406) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
基因
基因别称
Dhe
NCBI ID
染色体号
Chr 3
NCBI RefSeq
NM_001002011.3
Ensembl ID
ENSMUST00000029699
修饰方式
条件性基因敲除
靶向范围
Exon 2~5
敲除长度
~2.8 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成，建议您在购买前查询最新的数据库和相关文献，以获取最准确的表型信息。
表型提示
MGI:96794Homozygotes for targeted mutations exhibit retarded postnatal growth, muscular dystrophy, reduced fat stores, micrognathy, abnormal dentition, impaired gonadal development, malformed scapulae, hyperkeratosis, and die by 8 weeks of age. Heterozygosity for an atypical progeria syndrome (APS) associated mutation leads to changes in fat distribution, and diet-induced weight gain, insulin resistance, glucose intolerance and hypercholesteremia.
发表文献
Proceedings of the National Academy of Sciences of the United St
2024-10-01
Nuclear envelope budding inhibition slows down progerin-induced aging process
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