Anpep-flox 基因敲除小鼠

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产品名称

Anpep-flox 基因敲除小鼠

产品编号

S-CKO-03351

品系全称

C57BL/6JCya-Anpepem1flox/Cya

品系背景

C57BL/6JCya

品系编号

CKOCMP-16790-Anpep-B6J-VA

品系状态

使用本品系发表的文献需注明: Anpep-flox 基因敲除小鼠 mice (Strain S-CKO-03351) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
cKO小鼠库模型

基本信息

基因研究概述

质控标准

基因
基因全称
alanyl aminopeptidase, membrane
基因别称
AP-M,AP-N,Apn,Cd13,P150
染色体号
Chr 7 (Mouse)
转录本 ID
NCBI: NM_008486 | Ensembl: ENSMUST00000107392
修饰方式
条件性基因敲除
靶向范围
Exon 3~4
敲除长度
~0.8 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:5000466Mice homozygous for different knock-out alleles exhibit an increase in CD4+ thymocytes, altered macrophage adhesion, pathological neovascularization and/or altered mammary gland morphology during gestation.
ANPEP,也称为Aminopeptidase N,是一种膜结合型外酶,负责将肽类物质分解成单个氨基酸。ANPEP在多种生物学过程中发挥重要作用,包括蛋白质代谢、信号传导和免疫应答等。

ANPEP在多种疾病中发挥重要作用,包括糖尿病、高血压、肝脏疾病、癌症和心脏疾病等。ANPEP的基因多态性与糖尿病微血管并发症的发生发展有关[1]。ANPEP的基因多态性也与高血压的发生发展有关[4]。ANPEP的基因多态性还与非酒精性脂肪肝疾病的发生发展有关[2]。ANPEP的基因多态性与癌症的发生发展有关[7]。ANPEP的基因多态性与心脏疾病的发生发展有关[6]。

ANPEP在糖尿病微血管并发症中的作用机制可能与谷胱甘肽代谢和氧化还原稳态的破坏有关[3]。ANPEP在高血压中的作用机制可能与肾小管表达的增加有关[4]。ANPEP在肝脏疾病中的作用机制可能与肝脏疾病的血浆蛋白质组有关[2]。ANPEP在癌症中的作用机制可能与IL-22诱导的内皮细胞通透性和癌细胞迁移有关[5]。ANPEP在心脏疾病中的作用机制可能与心肌重塑有关[6]。

ANPEP在多种疾病中的作用机制复杂多样,涉及多种生物学过程。ANPEP的研究有助于深入理解疾病的发生发展机制,为疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Korvyakova, Ya E, Azarova, I E, Markina, D D, Solodilova, M A, Polonikov, A V. 2024. Polymorphisms of ANPEP Gene Are Associated with Microvascular Complications of Type 2 Diabetes. In Bulletin of experimental biology and medicine, 178, 79-85. doi:10.1007/s10517-024-06286-7. https://pubmed.ncbi.nlm.nih.gov/39576474/
2. Niu, Lili, Geyer, Philipp E, Wewer Albrechtsen, Nicolai J, Hofmann, Susanna M, Mann, Matthias. 2019. Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease. In Molecular systems biology, 15, e8793. doi:10.15252/msb.20188793. https://pubmed.ncbi.nlm.nih.gov/30824564/
3. Korvyakova, Yaroslava, Azarova, Iuliia, Klyosova, Elena, Solodilova, Maria, Polonikov, Alexey. 2024. The link between the ANPEP gene and type 2 diabetes mellitus may be mediated by the disruption of glutathione metabolism and redox homeostasis. In Gene, 935, 149050. doi:10.1016/j.gene.2024.149050. https://pubmed.ncbi.nlm.nih.gov/39489227/
4. Kotlo, Kumar, Hughes, Douglas E, Herrera, Victoria L M, Robey, R Brooks, Danziger, Robert S. 2007. Functional polymorphism of the Anpep gene increases promoter activity in the Dahl salt-resistant rat. In Hypertension (Dallas, Tex. : 1979), 49, 467-72. doi:. https://pubmed.ncbi.nlm.nih.gov/17242304/
5. Giannou, Anastasios D, Kempski, Jan, Shiri, Ahmad Mustafa, Gagliani, Nicola, Huber, Samuel. . Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22. In Immunity, 56, 125-142.e12. doi:10.1016/j.immuni.2022.12.014. https://pubmed.ncbi.nlm.nih.gov/36630911/
6. Xie, Rong, Yuan, Shuai, Hu, Guo, Wang, Dao Wen, Li, Huaping. 2024. Nuclear AGO2 promotes myocardial remodeling by activating ANKRD1 transcription in failing hearts. In Molecular therapy : the journal of the American Society of Gene Therapy, 32, 1578-1594. doi:10.1016/j.ymthe.2024.03.018. https://pubmed.ncbi.nlm.nih.gov/38475992/
7. Huang, Robert J, Wichmann, Ignacio A, Su, Andrew, Hwang, Joo Ha, Ji, Hanlee P. 2023. A spatially mapped gene expression signature for intestinal stem-like cells identifies high-risk precursors of gastric cancer. In bioRxiv : the preprint server for biology, , . doi:10.1101/2023.09.20.558462. https://pubmed.ncbi.nlm.nih.gov/37786704/