Htr1a-flox 基因敲除小鼠

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产品名称

Htr1a-flox 基因敲除小鼠

产品编号

S-CKO-03000

品系全称

C57BL/6JCya-Htr1aem1flox/Cya

品系背景

C57BL/6JCya

品系编号

CKOCMP-15550-Htr1a-B6J-VA

品系状态

使用本品系发表的文献需注明: Htr1a-flox 基因敲除小鼠 mice (Strain S-CKO-03000) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
cKO小鼠库模型

基本信息

基因研究概述

质控标准

基因
基因全称
5-hydroxytryptamine (serotonin) receptor 1A
基因别称
Gpcr18
染色体号
Chr 13 (Mouse)
转录本 ID
NCBI: NM_008308 | Ensembl: ENSMUST00000022235
修饰方式
条件性基因敲除
靶向范围
Exon 1
敲除长度
~1.4 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:96273Homozygotes for targeted null mutations show a common phenotype, including augmented anxious-like behavior in the elevated plus-maze, open-field, and novel object tests, reduced immobility in the forced-swim or tail-suspension test, and changes in density of 5-HTT binding in several brain regions.
Htr1a基因编码5-羟色胺1A受体(5-HT1A受体),这是一种在神经系统中广泛表达的G蛋白偶联受体。5-HT1A受体是5-羟色胺(也称为血清素)的一种受体亚型,5-羟色胺是一种重要的神经递质,参与调节情绪、睡眠、食欲、疼痛感知和认知功能。Htr1a基因的突变或遗传多态性可能影响5-HT1A受体的表达和功能,进而影响个体的行为和心理健康。

多项研究表明,Htr1a基因与多种精神疾病相关,包括自杀行为、抑郁症、焦虑症、精神分裂症和强迫症等。例如,一项系统评价和荟萃分析显示,Htr1a基因的rs6295多态性与自杀行为存在相关性,尤其是在隐性模型中[1]。然而,另一项荟萃分析的结果表明,Htr1a基因与自杀行为之间没有显著关联[2]。此外,Htr1a基因的遗传多态性还与注意缺陷多动障碍(ADHD)相关[3]。一项研究表明,Htr1a基因的rs6295、rs878567和rs1800044多态性与2型糖尿病合并抑郁症无关[4]。还有研究显示,Htr1a基因的rs6295多态性可能影响抗精神病药物在精神分裂症患者中的疗效,尤其是在改善阴性症状方面[5,6]。此外,Htr1a基因与1型糖尿病的易感性相关[7],以及与强迫症的关联性[8]。

综上所述,Htr1a基因编码的5-HT1A受体在神经系统中发挥重要作用,其遗传多态性可能影响个体的行为和心理健康。尽管已有一些研究揭示了Htr1a基因与精神疾病的相关性,但仍需进一步的研究来明确其具体作用机制和临床应用价值。

参考文献:
1. Hernández-Díaz, Yazmin, Tovilla-Zárate, Carlos Alfonso, Castillo-Avila, Rosa Giannina, Villar-Juárez, Guillermo Efrén, González-Castro, Thelma Beatriz. 2022. Association between the HTR1A rs6295 gene polymorphism and suicidal behavior: an updated meta-analysis. In European archives of psychiatry and clinical neuroscience, 273, 5-14. doi:10.1007/s00406-022-01500-x. https://pubmed.ncbi.nlm.nih.gov/36214900/
2. Angles, Miriam Rivera, Ocaña, Deysi Bermúdez, Medellín, Beatriz Camarena, Tovilla-Zárate, Carlos. . No association between the HTR1A gene and suicidal behavior: a meta-analysis. In Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 34, 38-42. doi:. https://pubmed.ncbi.nlm.nih.gov/22392387/
3. Kessi, Miriam, Duan, Haolin, Xiong, Juan, Peng, Jing, Yin, Fei. 2022. Attention-deficit/hyperactive disorder updates. In Frontiers in molecular neuroscience, 15, 925049. doi:10.3389/fnmol.2022.925049. https://pubmed.ncbi.nlm.nih.gov/36211978/
4. Yu, Xiao-Dan, Zhu, Yi, Sun, Qi-Xin, Li, Yulong, Li, Xiao-Ming. 2022. Distinct serotonergic pathways to the amygdala underlie separate behavioral features of anxiety. In Nature neuroscience, 25, 1651-1663. doi:10.1038/s41593-022-01200-8. https://pubmed.ncbi.nlm.nih.gov/36446933/
5. Simayi, Dilixia, Guan, Yaqun. 2022. HTR1A Gene Polymorphism in Type 2 Diabetes Mellitus Comorbid with Major Depressive Disorder in a Chinese Population. In Diabetes, metabolic syndrome and obesity : targets and therapy, 15, 1597-1604. doi:10.2147/DMSO.S361843. https://pubmed.ncbi.nlm.nih.gov/35651901/
6. Takekita, Yoshiteru, Fabbri, Chiara, Kato, Masaki, Kinoshita, Toshihiko, Serretti, Alessandro. 2016. HTR1A Polymorphisms and Clinical Efficacy of Antipsychotic Drug Treatment in Schizophrenia: A Meta-Analysis. In The international journal of neuropsychopharmacology, 19, . doi:10.1093/ijnp/pyv125. https://pubmed.ncbi.nlm.nih.gov/26568455/
7. Takekita, Yoshiteru, Fabbri, Chiara, Kato, Masaki, Kinoshita, Toshihiko, Serretti, Alessandro. . HTR1A Gene Polymorphisms and 5-HT1A Receptor Partial Agonist Antipsychotics Efficacy in Schizophrenia. In Journal of clinical psychopharmacology, 35, 220-7. doi:10.1097/JCP.0000000000000304. https://pubmed.ncbi.nlm.nih.gov/25822479/
8. Grubor, Mirko, Zivkovic, Maja, Sagud, Marina, Muck-Seler, Dorotea, Svob Strac, Dubravka. 2020. HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol-Treated Patients with Schizophrenia. In International journal of molecular sciences, 21, . doi:10.3390/ijms21072345. https://pubmed.ncbi.nlm.nih.gov/32231051/