Hint1-flox 基因敲除小鼠

1. Xu, Ling, Wang, Guangyu, Lv, Xiaoqing, Yan, Chuanzhu, Lin, Pengfei. 2022. A novel mutation in HINT1 gene causes autosomal recessive axonal neuropathy with neuromyotonia, effective treatment with carbamazepine and review of the literature. In Acta neurologica Belgica, 122, 1305-1312. doi:10.1007/s13760-022-02006-y. https://pubmed.ncbi.nlm.nih.gov/35767146/

2. Zhang, Yan, Da, Qiang, Cao, Siyi, Xie, Liping, Ji, Yong. 2021. HINT1 (Histidine Triad Nucleotide-Binding Protein 1) Attenuates Cardiac Hypertrophy Via Suppressing HOXA5 (Homeobox A5) Expression. In Circulation, 144, 638-654. doi:10.1161/CIRCULATIONAHA.120.051094. https://pubmed.ncbi.nlm.nih.gov/34098726/

3. Chen, Jie, Ruan, Xixian, Sun, Yuhao, Yuan, Shuai, Li, Xue. 2023. Multi-omic insight into the molecular networks of mitochondrial dysfunction in the pathogenesis of inflammatory bowel disease. In EBioMedicine, 99, 104934. doi:10.1016/j.ebiom.2023.104934. https://pubmed.ncbi.nlm.nih.gov/38103512/

4. Liu, Fei, Ma, Jing, Liu, Peng, Wang, Jia-Bei, Dang, Yong-Hui. 2016. Hint1 gene deficiency enhances the supraspinal nociceptive sensitivity in mice. In Brain and behavior, 6, e00496. doi:10.1002/brb3.496. https://pubmed.ncbi.nlm.nih.gov/27547499/

5. Shchagina, O A, Milovidova, T B, Murtazina, A F, Dadali, E L, Polyakov, A V. 2019. HINT1 gene pathogenic variants: the most common cause of recessive hereditary motor and sensory neuropathies in Russian patients. In Molecular biology reports, 47, 1331-1337. doi:10.1007/s11033-019-05238-z. https://pubmed.ncbi.nlm.nih.gov/31848916/

6. Liu, Peng, Liu, Zhongwei, Wang, Jiabei, Ma, Xiancang, Dang, Yonghui. 2017. HINT1 in Neuropsychiatric Diseases: A Potential Neuroplastic Mediator. In Neural plasticity, 2017, 5181925. doi:10.1155/2017/5181925. https://pubmed.ncbi.nlm.nih.gov/29214080/