Casq2-flox 基因敲除小鼠

1. Eldar, Michael, Pras, Elon, Lahat, Hadas. . A missense mutation in the CASQ2 gene is associated with autosomal-recessive catecholamine-induced polymorphic ventricular tachycardia. In Trends in cardiovascular medicine, 13, 148-51. doi:. https://pubmed.ncbi.nlm.nih.gov/12732448/

2. Denegri, Marco, Bongianino, Rossana, Lodola, Francesco, Napolitano, Carlo, Priori, Silvia G. 2014. Single delivery of an adeno-associated viral construct to transfer the CASQ2 gene to knock-in mice affected by catecholaminergic polymorphic ventricular tachycardia is able to cure the disease from birth to advanced age. In Circulation, 129, 2673-81. doi:10.1161/CIRCULATIONAHA.113.006901. https://pubmed.ncbi.nlm.nih.gov/24888331/

3. Kurtzwald-Josefson, Efrat, Yadin, Dor, Harun-Khun, Shiraz, Hochhauser, Edith, Arad, Michael. 2017. Viral delivered gene therapy to treat catecholaminergic polymorphic ventricular tachycardia (CPVT2) in mouse models. In Heart rhythm, 14, 1053-1060. doi:10.1016/j.hrthm.2017.03.025. https://pubmed.ncbi.nlm.nih.gov/28336343/

4. Ding, Yan, Yuan, Xiaoliang, Wang, Ying, Yan, Jun. . CASQ2 alleviates lung cancer by inhibiting M2 tumor-associated macrophage polarization and JAK/STAT pathway. In Journal of biochemical and molecular toxicology, 38, e23801. doi:10.1002/jbt.23801. https://pubmed.ncbi.nlm.nih.gov/39132772/