Akt2-flox 基因敲除小鼠

1. Mäkinen, Selina, Datta, Neeta, Rangarajan, Savithri, Laakso, Markku, Koistinen, Heikki A. 2023. Finnish-specific AKT2 gene variant leads to impaired insulin signalling in myotubes. In Journal of molecular endocrinology, 70, . doi:10.1530/JME-21-0285. https://pubmed.ncbi.nlm.nih.gov/36409629/

2. Ma, Fei Fei, Cao, Ding Ding, Ouyang, Shengrong, Li, Yuanyuan, Wu, Jianxin. 2016. Hypermethylation of AKT2 gene is associated with neural-tube defects in fetus. In Placenta, 48, 80-86. doi:10.1016/j.placenta.2016.10.010. https://pubmed.ncbi.nlm.nih.gov/27871477/

3. Li, Jie, Mo, Sien, Sun, Yan, Huang, Hua, Wang, Shujia. 2021. Association between AKT2 gene polymorphism and polycystic ovary syndrome: a case-control study. In Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 37, 635-639. doi:10.1080/09513590.2021.1932800. https://pubmed.ncbi.nlm.nih.gov/34044676/

4. Kannan, Kalpana, Coarfa, Cristian, Chao, Pei-Wen, Matzuk, Martin M, Yen, Laising. 2015. Recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma. In Proceedings of the National Academy of Sciences of the United States of America, 112, E1272-7. doi:10.1073/pnas.1501735112. https://pubmed.ncbi.nlm.nih.gov/25733895/

5. Elangeeb, M E, Elfaki, Imadeldin, Elkhalifa, M A, Amle, Dnyanesh, Mir, Rashid. 2023. In Silico Investigation of AKT2 Gene and Protein Abnormalities Reveals Potential Association with Insulin Resistance and Type 2 Diabetes. In Current issues in molecular biology, 45, 7449-7475. doi:10.3390/cimb45090471. https://pubmed.ncbi.nlm.nih.gov/37754255/

6. Ting, Kenneth K Y, Yu, Pei, Iyayi, Mudia, Jongstra-Bilen, Jenny, Cybulsky, Myron I. . Oxidized Low-Density Lipoprotein Accumulation in Macrophages Impairs Lipopolysaccharide-Induced Activation of AKT2, ATP Citrate Lyase, Acetyl-Coenzyme A Production, and Inflammatory Gene H3K27 Acetylation. In ImmunoHorizons, 8, 57-73. doi:10.4049/immunohorizons.2300101. https://pubmed.ncbi.nlm.nih.gov/38193847/

7. Sun, Weixia, Miao, Xiao, Zhou, Shanshan, Wang, Yuehui, Cai, Lu. 2014. Zinc rescue of Akt2 gene deletion-linked murine cardiac dysfunction and pathological changes is metallothionein-dependent. In Journal of molecular and cellular cardiology, 74, 88-97. doi:10.1016/j.yjmcc.2014.04.023. https://pubmed.ncbi.nlm.nih.gov/24819347/

8. Kamran, Mitra, Kharazmi, Fatemeh, Malekzadeh, Kianoosh, Khosravi, Fatemah, Soltani, Nepton. 2018. Effect of Long-term Administration of Oral Magnesium Sulfate and Insulin to Reduce Streptozotocin-Induced Hyperglycemia in Rats: the Role of Akt2 and IRS1 Gene Expressions. In Biological trace element research, 190, 396-404. doi:10.1007/s12011-018-1555-z. https://pubmed.ncbi.nlm.nih.gov/30519800/

9. Honardoost, Maryam, Rad, Seyed Mohammad Ali Hosseini. 2017. Triangle of AKT2, miRNA, and Tumorigenesis in Different Cancers. In Applied biochemistry and biotechnology, 185, 524-540. doi:10.1007/s12010-017-2657-3. https://pubmed.ncbi.nlm.nih.gov/29199386/