Adam8-flox 基因敲除小鼠

1. Schlomann, Uwe, Koller, Garrit, Conrad, Catharina, Nimsky, Christopher, Bartsch, Jörg W. 2015. ADAM8 as a drug target in pancreatic cancer. In Nature communications, 6, 6175. doi:10.1038/ncomms7175. https://pubmed.ncbi.nlm.nih.gov/25629724/

2. Conrad, Catharina, Yildiz, Daniela, Cleary, Simon J, Looney, Mark R, Bartsch, Jörg W. 2022. ADAM8 signaling drives neutrophil migration and ARDS severity. In JCI insight, 7, . doi:10.1172/jci.insight.149870. https://pubmed.ncbi.nlm.nih.gov/35132956/

3. Conrad, Catharina, Götte, Malena, Schlomann, Uwe, Nimsky, Christopher, Bartsch, Jörg W. 2017. ADAM8 expression in breast cancer derived brain metastases: Functional implications on MMP-9 expression and transendothelial migration in breast cancer cells. In International journal of cancer, 142, 779-791. doi:10.1002/ijc.31090. https://pubmed.ncbi.nlm.nih.gov/28986926/

4. Raitoharju, Emma, Seppälä, Ilkka, Levula, Mari, Kähönen, Mika, Lehtimäki, Terho. 2011. Common variation in the ADAM8 gene affects serum sADAM8 concentrations and the risk of myocardial infarction in two independent cohorts. In Atherosclerosis, 218, 127-33. doi:10.1016/j.atherosclerosis.2011.05.005. https://pubmed.ncbi.nlm.nih.gov/21640993/

5. Duan, Biao, Liu, Yan, Hu, He, Wang, Yong, Li, Zhe-Hai. 2019. Notch1-ADAM8 positive feed-back loop regulates the degradation of chondrogenic extracellular matrix and osteoarthritis progression. In Cell communication and signaling : CCS, 17, 134. doi:10.1186/s12964-019-0443-2. https://pubmed.ncbi.nlm.nih.gov/31640732/

6. Oreo, K M, Gibson, P G, Simpson, J L, McDonald, V M, Baines, K J. . Sputum ADAM8 expression is increased in severe asthma and COPD. In Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 44, 342-52. doi:10.1111/cea.12223. https://pubmed.ncbi.nlm.nih.gov/24147597/