Prdm15-flox 基因敲除小鼠

1. Mzoughi, Slim, Fong, Jia Yi, Papadopoli, David, Topisirovic, Ivan, Guccione, Ernesto. 2020. PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis. In Nature communications, 11, 3520. doi:10.1038/s41467-020-17064-0. https://pubmed.ncbi.nlm.nih.gov/32665551/

2. Mann, Nina, Mzoughi, Slim, Schneider, Ronen, Zenker, Martin, Hildebrandt, Friedhelm. 2021. Mutations in PRDM15 Are a Novel Cause of Galloway-Mowat Syndrome. In Journal of the American Society of Nephrology : JASN, 32, 580-596. doi:10.1681/ASN.2020040490. https://pubmed.ncbi.nlm.nih.gov/33593823/

3. Mzoughi, Slim, Di Tullio, Federico, Low, Diana H P, Messerschmidt, Daniel M, Guccione, Ernesto. 2020. PRDM15 loss of function links NOTCH and WNT/PCP signaling to patterning defects in holoprosencephaly. In Science advances, 6, eaax9852. doi:10.1126/sciadv.aax9852. https://pubmed.ncbi.nlm.nih.gov/31950080/

4. Mzoughi, Slim, Zhang, Jingxian, Hequet, Delphine, Messerschmidt, Daniel M, Guccione, Ernesto. 2017. PRDM15 safeguards naive pluripotency by transcriptionally regulating WNT and MAPK-ERK signaling. In Nature genetics, 49, 1354-1363. doi:10.1038/ng.3922. https://pubmed.ncbi.nlm.nih.gov/28740264/