Slco1a5-flox 基因敲除小鼠

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产品名称

Slco1a5-flox 基因敲除小鼠

产品编号

S-CKO-00649

品系全称

C57BL/6JCya-Slco1a5em1flox/Cya

品系背景

C57BL/6JCya

品系编号

CKOCMP-108096-Slco1a5-B6J-VA

品系状态

使用本品系发表的文献需注明: Slco1a5-flox 基因敲除小鼠 mice (Strain S-CKO-00649) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
cKO小鼠库模型

基本信息

基因研究概述

质控标准

基因
基因全称
solute carrier organic anion transporter family, member 1a5
基因别称
Oatp-3,Oatp3,Slc21a7
染色体号
Chr 6 (Mouse)
转录本 ID
NCBI: NM_001267707.1 | Ensembl: ENSMUST00000111825
修饰方式
条件性基因敲除
靶向范围
Exon 3
敲除长度
~642 bp
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:1351865Homozygous mutation of this gene results in decreased percentage of CD8 ells and increased percentage of B cells in the peripheral blood.
基因Slco1a5,也称为有机阴离子转运多肽3(OATP3),是一种在多种组织中表达的蛋白质。它属于有机阴离子转运蛋白(OATP)家族,负责将多种内源性物质和外来物质转运进入细胞内。Slco1a5在药物代谢和毒性方面发挥着重要作用,同时也与多种生物学过程和疾病发生机制相关。

Slco1a5在肝脏中表达较高,负责将内源性物质和药物转运进入肝细胞,参与药物的代谢和解毒过程。此外,Slco1a5还在肾脏中表达,参与药物的排泄过程。Slco1a5在肠道中也存在表达,可能参与肠道对药物的吸收。此外,Slco1a5还在大脑中表达,可能参与药物的脑内转运和药物在脑内的代谢过程。

Slco1a5的表达受到多种因素的影响,包括年龄、性别和药物等。研究表明,Slco1a5在发育和衰老过程中会发生动态变化,且在不同性别之间也存在差异。此外,Slco1a5的表达还受到药物的调节,例如,EGCG可以下调Slco1a5的表达水平,从而影响药物的吸收和代谢过程。

Slco1a5在药物代谢和毒性方面发挥着重要作用。例如,Slco1a5可以转运多种药物,包括心血管药物、抗肿瘤药物和抗生素等。Slco1a5的表达水平会影响药物的吸收、分布、代谢和排泄,从而影响药物的疗效和毒性。此外,Slco1a5的基因多态性也与药物的疗效和毒性相关。

Slco1a5还与多种生物学过程和疾病发生机制相关。例如,Slco1a5在视网膜中表达,可能参与视网膜对药物的转运和代谢过程。Slco1a5在鼻腔上皮细胞中也存在表达,可能参与鼻腔给药药物的转运和吸收过程。此外,Slco1a5在血脑屏障中也存在表达,可能参与药物在脑内的转运和代谢过程。

Slco1a5在多种疾病中发挥重要作用。例如,Slco1a5与心血管疾病、癌症和神经系统疾病等的发生和发展相关。Slco1a5的表达水平会影响疾病的发病风险和治疗效果。

综上所述,Slco1a5是一种重要的有机阴离子转运蛋白,在药物代谢和毒性方面发挥着重要作用,同时也与多种生物学过程和疾病发生机制相关。Slco1a5的研究有助于深入理解药物的代谢和毒性机制,为疾病的治疗和预防提供新的思路和策略[1,2,3,4,5,6,7,8]。

参考文献:
1. Lin, Jian-dong, Lin, Ming-rui, Xiao, Xiong-jian. . [The effect of ulinastatin on gene expression of brain tissue in septic rat]. In Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 23, 490-4. doi:. https://pubmed.ncbi.nlm.nih.gov/21878175/
2. Hosoya, Ken-ichi, Hori, Satoko, Ohtsuki, Sumio, Terasaki, Tetsuya. . A new in vitro model for blood-cerebrospinal fluid barrier transport studies: an immortalized choroid plexus epithelial cell line derived from the tsA58 SV40 large T-antigen gene transgenic rat. In Advanced drug delivery reviews, 56, 1875-85. doi:. https://pubmed.ncbi.nlm.nih.gov/15381338/
3. Hou, Wei-Yu, Xu, Shang-Fu, Zhu, Qiong-Ni, Cheng, Xing-Guo, Liu, Jie. 2014. Age- and sex-related differences of organic anion-transporting polypeptide gene expression in livers of rats. In Toxicology and applied pharmacology, 280, 370-7. doi:10.1016/j.taap.2014.08.020. https://pubmed.ncbi.nlm.nih.gov/25168429/
4. Genter, Mary Beth, Krishan, Mansi, Augustine, Lisa M, Cherrington, Nathan J. 2010. Drug transporter expression and localization in rat nasal respiratory and olfactory mucosa and olfactory bulb. In Drug metabolism and disposition: the biological fate of chemicals, 38, 1644-7. doi:10.1124/dmd.110.034611. https://pubmed.ncbi.nlm.nih.gov/20660103/
5. Tan, Hong-Jie, Ling, Wei-Chih, Chua, Ang-Lim, Lee, Siew-Keah. 2021. Oral epigallocatechin gallate reduces intestinal nadolol absorption via modulation of Oatp1a5 and Oct1 transcriptional levels in spontaneously hypertensive rats. In Phytomedicine : international journal of phytotherapy and phytopharmacology, 90, 153623. doi:10.1016/j.phymed.2021.153623. https://pubmed.ncbi.nlm.nih.gov/34303263/
6. Ito, Aki, Yamaguchi, Katsuhiro, Onogawa, Tohru, Abe, Takaaki, Tamai, Makoto. . Distribution of organic anion-transporting polypeptide 2 (oatp2) and oatp3 in the rat retina. In Investigative ophthalmology & visual science, 43, 858-63. doi:. https://pubmed.ncbi.nlm.nih.gov/11867608/
7. Kusuhara, Hiroyuki, He, Zhonggui, Nagata, Yoshinori, Abe, Takaaki, Sugiyama, Yuichi. . Expression and functional involvement of organic anion transporting polypeptide subtype 3 (Slc21a7) in rat choroid plexus. In Pharmaceutical research, 20, 720-7. doi:. https://pubmed.ncbi.nlm.nih.gov/12751626/
8. Suzuki, Motoya, Komura, Hiroshi, Yoshikawa, Tomonori, Takubo, Hiroaki, Kogayu, Motohiro. 2014. Characterization of gastrointestinal absorption of digoxin involving influx and efflux transporter in rats: application of mdr1a knockout (-/-) rats into absorption study of multiple transporter substrate. In Xenobiotica; the fate of foreign compounds in biological systems, 44, 1039-45. doi:10.3109/00498254.2014.920551. https://pubmed.ncbi.nlm.nih.gov/24839994/