智鼠故事 
Trp53 KO 小鼠
复苏/繁育服务
自发肿瘤模型
* 使用本品系发表的文献需注明：Trp53 KO 小鼠 mice (Catalog C001203) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
只
基本信息
产品名称
Trp53 KO 小鼠
产品编号
C001203
基因名
品系背景
C57BL/6JCya
基因别称
bbl；bfy；bhy；p44；p53；Tp53
模型分类
自发肿瘤模型
NCBI ID
小鼠表型
染色体
11
更多信息
* 使用本品系发表的文献需注明：Trp53 KO 小鼠 mice (Catalog C001203) were purchased from Cyagen.
品系描述
本模型为Trp53基因敲除小鼠，Trp53 KO纯合雄鼠发育正常，但易患自发性肿瘤。纯合雄鼠是可存活且可育的。纯合雌鼠在断奶时存活率降低。
相关疾病：
Li-Fraumeni Syndrome
Papilloma of Choroid Plexus
Osteogenic Sarcoma
Glioma Susceptibility 1
Basal Cell Carcinoma 7
Adrenocortical Carcinoma, Hereditary
Bone Marrow Failure Syndrome 5
Pancreatic Cancer
Leukemia, Chronic Lymphocytic
Choroid Plexus Cancer
Hepatocellular Carcinoma
Nasopharyngeal Carcinoma
Bone Osteosarcoma
Li-Fraumeni Syndrome 1
Colorectal Cancer
Squamous Cell Carcinoma
Rhabdomyosarcoma
Sarcoma
Gallbladder Cancer
Plasma Cell Neoplasm
Anaplastic Astrocytoma
Thyroid Gland Anaplastic Carcinoma
Malignant Astrocytoma
Ductal Carcinoma in Situ
Cervix Carcinoma
Breast Adenocarcinoma
Tongue Disease
Pleomorphic Xanthoastrocytoma
Congenital Fibrosarcoma
Adrenal Cortical Carcinoma
Cervical Cancer
Lip and Oral Cavity Cancer
Diffuse Large B-Cell Lymphoma
Lymphoma, Hodgkin, Classic
Atypical Teratoid Rhabdoid Tumor
Lung Sarcomatoid Carcinoma
High-Grade Astrocytoma
Small Cell Cancer of the Lung
Lung Cancer Susceptibility 3
Embryonal Rhabdomyosarcoma
Pleomorphic Rhabdomyosarcoma
Myeloma, Multiple
Hepatoblastoma
Pancytopenia
Acute Megakaryocytic Leukemia
Squamous Cell Carcinoma, Head and Neck
Bladder Cancer
Esophageal Cancer
Rhabdomyosarcoma 2
Thyroid Cancer, Nonmedullary, 1
Hereditary Breast Ovarian Cancer Syndrome
Lymphoma, Non-Hodgkin, Familial
Ovarian Cancer
Conn's Syndrome
Lung Cancer
Gastric Cancer
Prostate Cancer
Leukemia, Acute Myeloid
Diamond-Blackfan Anemia
Diamond-Blackfan Anemia 1
Adenocarcinoma
Ovarian Serous Cystadenocarcinoma
Pancreatic Adenocarcinoma
Diffuse Pediatric-Type High-Grade Glioma, H3-Wildtype and Idh-Wildtype
Small-Cell Carcinoma of the Ovary of Hypercalcemic Type
Uterine Carcinosarcoma
Adenoid Cystic Carcinoma
Gliosarcoma
Lung Oat Cell Carcinoma
Bladder Urothelial Carcinoma
Suppression of Tumorigenicity 12
Giant Cell Glioblastoma
Skin Melanoma
Skin Squamous Cell Carcinoma
Brain Cancer
Brain Stem Glioma
Adult Hepatocellular Carcinoma
Head and Neck Cancer
Lung Squamous Cell Carcinoma
Lymphoma
Gastric Adenocarcinoma
Essential Thrombocythemia
Renal Cell Carcinoma, Papillary, 1
Glioblastoma
B-Lymphoblastic Leukemia/lymphoma with T(9;22)(q34.1;q11.2)
Medulloblastoma
Neuroblastoma
Myelodysplastic Syndrome
Renal Cell Carcinoma, Nonpapillary
应用领域
家族性乳腺癌研究（例如Li-Fraumeni综合征）以及肺、脑和骨肿瘤，淋巴瘤和白血病等其他罕见癌症的研究
发表文献
Digestive Diseases and Sciences
2020.01
* 使用本品系发表的文献需注明：Trp53 KO 小鼠 mice (Catalog C001203) were purchased from Cyagen.
