Serpina1(a-e) KO小鼠_代谢及心血管模型小鼠_构建

Serpina1(a-e) KO 小鼠是一种基因敲除（KO）模型，利用基因编辑技术敲除了小鼠 Serpina1(a-e)基因（人类 SERPINA1 基因的同源基因）的蛋白编码序列。初步数据表明，小鼠肝脏中 Serpina1 基因的表达几乎缺失，在 8 周龄时尚未观察到明显的肺部异常病变。Serpina1(a-e) KO 小鼠可应用于肺气肿、慢性阻塞性肺疾病（COPD）、肝硬化和肝细胞癌的发病机制研究以及相关治疗策略的研发。

相关疾病：

Alpha-1-Antitrypsin Deficiency

Hemorrhagic Disease Due to Alpha-1-Antitrypsin Pittsburgh Mutation

Pulmonary Disease, Chronic Obstructive

Fraxe Intellectual Disability

Intellectual Developmental Disorder, X-Linked 109

Fragile X Syndrome

Cystic Fibrosis

Alpha-1-Antitrypsin Deficiency

Hemorrhagic Disease Due to Alpha-1-Antitrypsin Pittsburgh Mutation

Pulmonary Disease, Chronic Obstructive

Fraxe Intellectual Disability

Intellectual Developmental Disorder, X-Linked 109

Fragile X Syndrome

Cystic Fibrosis

Alpha-1-Antitrypsin Deficiency

Hemorrhagic Disease Due to Alpha-1-Antitrypsin Pittsburgh Mutation

Pulmonary Disease, Chronic Obstructive

Fraxe Intellectual Disability

Intellectual Developmental Disorder, X-Linked 109

Fragile X Syndrome

Cystic Fibrosis

Alpha-1-Antitrypsin Deficiency

Hemorrhagic Disease Due to Alpha-1-Antitrypsin Pittsburgh Mutation

Pulmonary Disease, Chronic Obstructive

Fraxe Intellectual Disability

Intellectual Developmental Disorder, X-Linked 109

Fragile X Syndrome

Cystic Fibrosis

Alpha-1-Antitrypsin Deficiency

Hemorrhagic Disease Due to Alpha-1-Antitrypsin Pittsburgh Mutation

Pulmonary Disease, Chronic Obstructive

Fraxe Intellectual Disability

Intellectual Developmental Disorder, X-Linked 109

Fragile X Syndrome

Cystic Fibrosis

应用领域

肺气肿和慢性阻塞性肺疾病（COPD）的发病机制研究及治疗药物评价

肝硬化或肝细胞癌的发病机制研究及治疗药物评价