智鼠故事 
Lcn2-DTR-EGFP 小鼠
复苏/繁育服务
产品名称：
Lcn2-DTR-EGFP 小鼠
产品编号：
C001757
品系背景：
C57BL/6JCya
表达组织/细胞举例：
成骨细胞、白色脂肪组织、肝脏、星形胶质细胞、肾脏及Lcn2阳性细胞
* 使用本品系发表的文献需注明：Lcn2-DTR-EGFP 小鼠 mice (Catalog C001757) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
只
品系描述
通过基因编辑技术将小鼠Lcn2基因TGA终止密码子替换为P2A-DTR-EGFP基因表达元件，即在小鼠Lcn2基因调控元件的驱动下表达DTR（白喉毒素受体）和EGFP荧光蛋白，且不会影响小鼠内源Lcn2基因的表达。Lcn2阳性细胞显示绿色荧光，此时注射白喉毒素（DT）即可选择性清除这些细胞。本模型可实现EGFP荧光蛋白示踪研究。
相关疾病：
Pyuria
Appendicitis
Hepatorenal Syndrome
Acute Kidney Failure
Pyelonephritis
Hydronephrosis
Kidney Disease
Proctitis
Leptospirosis
Chronic Kidney Disease
Acute Kidney Tubular Necrosis
Glomerulonephritis
Pelvic Inflammatory Disease
Hidradenitis Suppurativa
Danubian Endemic Familial Nephropathy
Congenital Anomalies of Kidney and Urinary Tract 2
Cardiac Arrest
Hidradenitis
Otitis Media
Vasculitis
Hypoplastic Left Heart Syndrome
Anuria
Pyelitis
Hyperuricemia
Peritonitis
Urinary Tract Infection
Acute Pyelonephritis
Endocarditis
Trypanosomiasis
Inferolateral Myocardial Infarct
Type 1 Diabetes Mellitus 19
Nephrolithiasis
Systemic Lupus Erythematosus
Transient Cerebral Ischemia
Autoimmune Optic Neuritis
Colitis
Ventricular Tachycardia, Catecholaminergic Polymorphic, 4
Beta-Thalassemia
Cholesterol Embolism
Aortic Aneurysm
Interstitial Nephritis
Bacterial Infectious Disease
Urinary Tract Obstruction
Type 2 Diabetes Mellitus
Inflammatory Bowel Disease
Chronic Salpingo-Oophoritis
Polyneuropathy
Acute Cystitis
Bacteriuria
Pancreatic Cancer
Acute Salpingo-Oophoritis
Ureteral Disease
Renal Artery Disease
Obstructive Nephropathy
Nephrotic Syndrome
Malaria
Bowel Dysfunction
Asthma
Myocardial Infarction
Vesicoureteral Reflux
Diabetes Mellitus
Cystic Fibrosis
Hypertension, Essential
Ovarian Cancer
Autosomal Dominant Polycystic Kidney Disease
Esophageal Cancer
Body Mass Index Quantitative Trait Locus 11
Cystic Kidney Disease
Prostate Cancer
Aortic Aneurysm, Familial Abdominal, 1
Patent Ductus Arteriosus 1
Stroke, Ischemic
Polycystic Kidney Disease
