智鼠故事 
C57BL/6NCya-Sirt3em1/Cya 全身性基因敲除小鼠
复苏/繁育服务
产品名称
Sirt3-KO
产品编号
S-KO-11422
品系全称
C57BL/6NCya-Sirt3em1/Cya
品系背景
C57BL/6NCya
品系状态
冻存精子
品系编号
KOCMP-64384-Sirt3-B6N-VA
使用本品系发表的文献需注明： Sirt3-KO mice (Strain S-KO-11422) were purchased from Cyagen.
产品类型
周龄
性别
基因型
数量
基因
基因别称
Sir2l3，2310003L23Rik
NCBI ID
染色体号
Chr 7
NCBI RefSeq
NM_022433
Ensembl ID
ENSMUST00000026559
修饰方式
全身性基因敲除
靶向范围
Exon 4
敲除长度
~0.1 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成，建议您在购买前查询最新的数据库和相关文献，以获取最准确的表型信息。
表型提示
MGI:1927665Mice homozygous for one null allele exhibit increased systolic blood pressure while mice homozygous for another allele exhibit reduced ATP production.
发表文献
Frontiers in Immunology
2023-05-19
SIRT3 alleviates imiquimod-induced psoriatic dermatitis through deacetylation of XBP1s and modulation of TLR7/8 inducing IL-23 production in macrophages
Acta Pharmacologica Sinica
2022-12-05
Poricoic acid A suppresses renal fibroblast activation and interstitial fibrosis in UUO rats via upregulating Sirt3 and promoting β-catenin K49 deacetylation
CELL PROLIFERATION
2022-11-01
Sirt3 mitigates LPS-induced mitochondrial damage in renal tubular epithelial cells by deacetylating YME1L1
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