智鼠故事 
C57BL/6JCya-Ezh2em1/Cya 全身性基因敲除小鼠
复苏/繁育服务
产品名称
Ezh2-KO
产品编号
S-KO-01960
品系全称
C57BL/6JCya-Ezh2em1/Cya
品系背景
C57BL/6JCya
品系编号
KOCMP-14056-Ezh2-B6J-VA
品系状态
使用本品系发表的文献需注明： Ezh2-KO mice (Strain S-KO-01960) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
基因
基因别称
KMT6，Enx-1，Enx1h，mKIAA4065
NCBI ID
染色体号
Chr 6
NCBI RefSeq
NM_007971
Ensembl ID
ENSMUST00000081721
修饰方式
全身性基因敲除
靶向范围
Exon 5
敲除长度
~1.5 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成，建议您在购买前查询最新的数据库和相关文献，以获取最准确的表型信息。
表型提示
MGI:107940Homozygous null mutants die prior to completing gastrulation. A conditional mutant with loss of expression in immune cells survives, but has defects in early B cell development and Igh rearrangement. Conditional loss of maternal protein results in severe growth retardation of neonates. Conditional loss in oligodendrocytes affects their maturation and delays subsequent myelinization of axons in the central nervous system by oligodendrocytes. Homozygosity for a catalytically defective mutant is embryonic lethal, while heterozygosity affects bone formation and leads to increased body weight in females.
