Abcc2位于小鼠的19号染色体,采用CRISPR/Cas技术,设计sgRNA和ssDNA,通过高通量电转受精卵方式,获得Abcc2基因条件性敲除小鼠,性成熟后取精子冻存。
相关疾病:
Dubin-Johnson Syndrome
Pseudoxanthoma Elasticum
Cholestasis
Colorectal Cancer
Lung Cancer
Ovarian Cancer
Hepatocellular Carcinoma
Intrahepatic Cholestasis
Liver Disease
Bilirubin Metabolic Disorder