Tmem200a,即跨膜蛋白200A,是一种在人类癌症和免疫浸润中起作用的蛋白质。根据多组学分析,Tmem200a在多种人类癌症类型中表达水平较高,尤其是在胃癌(GC)中。生物信息学分析表明,Tmem200a可能作为一种诊断和预后生物标志物,在癌症的发生发展中发挥作用[1]。在体外细胞培养实验中,敲低Tmem200a的表达能够抑制GC细胞的增殖,降低细胞上皮-间质转化(EMT)相关蛋白的表达,并抑制PI3K/AKT信号通路的激活[1]。此外,Tmem200a的高表达与GC患者的预后不良相关,可能是GC患者生存率的独立危险因素[2]。
除了在GC中的作用,Tmem200a还与其他类型的癌症相关。例如,在卵巢癌中,Tmem200a的表达与药物抵抗和EMT的发生发展有关[4]。在急性髓系白血病(AML)中,Tmem200a的表达水平与患者的预后相关,可以作为预测AML患者预后的潜在生物标志物[5]。
除了在癌症中的作用,Tmem200a还与糖尿病的发生发展相关。一项全基因组关联研究发现,Tmem200a与脂肪形态的调节有关,可能影响脂肪细胞的分化和发育[3]。
综上所述,Tmem200a在多种癌症的发生发展和预后中发挥重要作用,可能作为一种潜在的生物标志物和治疗靶点。此外,Tmem200a还与糖尿病的发生发展相关,为糖尿病的预防和治疗提供了新的思路和策略。
参考文献:
1. Zhang, Yaowen, Kuang, Shanshan, Qin, Hancheng, Yang, Yixin, Xie, Jisheng. 2023. Multiomics Analysis of TMEM200A as a Pan-Cancer Biomarker. In Journal of visualized experiments : JoVE, , . doi:10.3791/65795. https://pubmed.ncbi.nlm.nih.gov/37782103/
2. Deng, Hongyang, Li, Tengfei, Wei, Fengxian, Xu, Xiaodong, Zhang, Youcheng. 2023. High expression of TMEM200A is associated with a poor prognosis and immune infiltration in gastric cancer. In Pathology oncology research : POR, 29, 1610893. doi:10.3389/pore.2023.1610893. https://pubmed.ncbi.nlm.nih.gov/36741965/
3. Lundbäck, Veroniqa, Kulyté, Agné, Arner, Peter, Strawbridge, Rona J, Dahlman, Ingrid. 2020. Genome-Wide Association Study of Diabetogenic Adipose Morphology in the GENetics of Adipocyte Lipolysis (GENiAL) Cohort. In Cells, 9, . doi:10.3390/cells9051085. https://pubmed.ncbi.nlm.nih.gov/32349335/
4. Kralj, Juran, Pernar Kovač, Margareta, Dabelić, Sanja, Köhrer, Karl, Brozovic, Anamaria. 2023. Transcriptome analysis of newly established carboplatin-resistant ovarian cancer cell model reveals genes shared by drug resistance and drug-induced EMT. In British journal of cancer, 128, 1344-1359. doi:10.1038/s41416-023-02140-1. https://pubmed.ncbi.nlm.nih.gov/36717670/
5. Nie, Lirong, Zhang, Yuming, You, Yuchan, Luo, Wenying, He, Honghua. . The signature based on seven genomic instability-related genes could predict the prognosis of acute myeloid leukemia patients. In Hematology (Amsterdam, Netherlands), 27, 840-848. doi:10.1080/16078454.2022.2107970. https://pubmed.ncbi.nlm.nih.gov/35924822/