Nkx6-3-flox 基因敲除小鼠

1. Yoon, Jung Hwan, Choi, Won Suk, Kim, Olga, Lee, Jung Young, Park, Won Sang. . NKX6.3 controls gastric differentiation and tumorigenesis. In Oncotarget, 6, 28425-39. doi:10.18632/oncotarget.4952. https://pubmed.ncbi.nlm.nih.gov/26314965/

2. Spracklen, Cassandra N, Horikoshi, Momoko, Kim, Young Jin, Mohlke, Karen L, Sim, Xueling. 2020. Identification of type 2 diabetes loci in 433,540 East Asian individuals. In Nature, 582, 240-245. doi:10.1038/s41586-020-2263-3. https://pubmed.ncbi.nlm.nih.gov/32499647/

3. Valsesia, Armand, Wang, Qiao-Ping, Gheldof, Nele, Neely, Greg G, Hager, Jörg. 2019. Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism. In Nature communications, 10, 540. doi:10.1038/s41467-019-08492-8. https://pubmed.ncbi.nlm.nih.gov/30710084/

4. Yoon, Jung Hwan, Kim, Olga, Nam, Suk Woo, Lee, Jung Young, Park, Won Sang. 2017. NKX6.3 Regulates Reactive Oxygen Species Production by Suppressing NF-kB and DNMT1 Activities in Gastric Epithelial Cells. In Scientific reports, 7, 2807. doi:10.1038/s41598-017-02901-y. https://pubmed.ncbi.nlm.nih.gov/28584243/

5. Yoon, Jung Hwan, Kim, Olga, Eun, Jung Woo, Nam, Suk Woo, Park, Won Sang. 2018. Multiple genetic mutations caused by NKX6.3 depletion contribute to gastric tumorigenesis. In Scientific reports, 8, 17609. doi:10.1038/s41598-018-35733-5. https://pubmed.ncbi.nlm.nih.gov/30514953/